Detailed information of TA system TA184702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1577465..1577946
• Replicon: chromosome
• Accession: NZ_CP066567
• Organism: Histophilus somni strain ASc-MMNZ-VFA-079

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL60_RS07635
• Protein ID: WP_165942816.1
• Coordinates: 1577686..1577946 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL60_RS07630
• Protein ID: WP_011608602.1
• Coordinates: 1577465..1577686 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL60_RS07620	1575469..1577028	-	1560	Protein_1471	transferrin-binding protein-like solute binding protein	-
JFL60_RS07625	1577304..1577402	-	99	Protein_1472	IS200/IS605 family transposase	-
JFL60_RS07630	1577465..1577686	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFL60_RS07635	1577686..1577946	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL60_RS07640	1578125..1579582	-	1458	WP_132994700.1	DUF560 domain-containing protein	-
JFL60_RS07645	1580067..1580486	-	420	WP_075321652.1	pseudouridine synthase	-
JFL60_RS07650	1580552..1581892	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1572358..1582863	10505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T184702 WP_165942816.1 NZ_CP066567:1577686-1577946 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184702 NZ_CP087784:c671152-670925 [Moraxella bovis]
ATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCAAGTCATGGTTTTTCATCGCCCACACCCAAGCCC
AAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATGGCATGGGTATCACACCATTAGATGACGACAGCC
AAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACTCATGAACACAATGACAATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184702 WP_011608602.1 NZ_CP066567:1577465-1577686 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184702 NZ_CP087784:c670944-670609 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA