Detailed information of TA system TA184699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1578168..1578649
• Replicon: chromosome
• Accession: NZ_CP066566
• Organism: Histophilus somni strain ASc-MMNZ-VFA-078

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL59_RS07675
• Protein ID: WP_165942816.1
• Coordinates: 1578389..1578649 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL59_RS07670
• Protein ID: WP_011608602.1
• Coordinates: 1578168..1578389 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL59_RS07660	1576200..1577731	-	1532	Protein_1479	transferrin-binding protein-like solute binding protein	-
JFL59_RS07665	1578007..1578105	-	99	Protein_1480	IS200/IS605 family transposase	-
JFL59_RS07670	1578168..1578389	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFL59_RS07675	1578389..1578649	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL59_RS07680	1578828..1580285	-	1458	WP_132994700.1	DUF560 domain-containing protein	-
JFL59_RS07685	1580770..1581189	-	420	WP_075321652.1	pseudouridine synthase	-
JFL59_RS07690	1581255..1582595	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T184699 WP_165942816.1 NZ_CP066566:1578389-1578649 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184699 NZ_CP087784:c100642-100307 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184699 WP_011608602.1 NZ_CP066566:1578168-1578389 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184699 NZ_CP087784:c100317-100036 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA