Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 436850..437582 Replicon chromosome
Accession NZ_CP066566
Organism Histophilus somni strain ASc-MMNZ-VFA-078

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JFL59_RS02300 Protein ID WP_011609926.1
Coordinates 437115..437582 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFL59_RS02295 Protein ID WP_011609927.1
Coordinates 436850..437113 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL59_RS02275 433138..435411 + 2274 WP_198986486.1 hypothetical protein -
JFL59_RS02280 435756..436010 + 255 WP_198986229.1 hypothetical protein -
JFL59_RS02285 436131..436400 + 270 WP_011609929.1 DUF1778 domain-containing protein -
JFL59_RS02290 436476..436712 + 237 WP_011609928.1 hypothetical protein -
JFL59_RS02295 436850..437113 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFL59_RS02300 437115..437582 + 468 WP_011609926.1 GNAT family N-acetyltransferase Toxin
JFL59_RS02305 437932..438165 - 234 WP_011609925.1 hypothetical protein -
JFL59_RS02310 438343..438609 - 267 Protein_445 hemophilus-specific protein -
JFL59_RS02315 438789..439235 - 447 WP_011609888.1 hypothetical protein -
JFL59_RS02320 439453..439785 - 333 WP_011609887.1 hypothetical protein -
JFL59_RS02325 439938..440075 - 138 WP_157856877.1 hypothetical protein -
JFL59_RS02330 440156..440803 - 648 WP_011609885.1 DUF3560 domain-containing protein -
JFL59_RS02335 440965..441258 - 294 WP_165942798.1 hypothetical protein -
JFL59_RS02340 441420..441734 - 315 WP_198986487.1 hypothetical protein -
JFL59_RS02345 441946..442410 - 465 WP_011609881.1 DUF3577 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17307.31 Da        Isoelectric Point: 10.5068

>T184698 WP_011609926.1 NZ_CP066566:437115-437582 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALKNRQNRASRTFVICNENVVVGFYALAAGSVTQRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T184698 NZ_CP087781:c2328939-2328751 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184698 WP_011609927.1 NZ_CP066566:436850-437113 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184698 NZ_CP087781:c2328688-2328281 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References