Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1723917..1724649 Replicon chromosome
Accession NZ_CP066565
Organism Histophilus somni strain ASc-MMNZ-VFA-076

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JFL57_RS07745 Protein ID WP_075294106.1
Coordinates 1723917..1724384 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFL57_RS07750 Protein ID WP_011609927.1
Coordinates 1724386..1724649 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL57_RS07710 1718995..1719441 + 447 WP_075293401.1 hypothetical protein -
JFL57_RS07715 1719460..1720389 - 930 WP_075293400.1 hypothetical protein -
JFL57_RS07720 1720645..1721781 - 1137 WP_198986874.1 transposase -
JFL57_RS07725 1721828..1722244 + 417 WP_075319814.1 IS200/IS605 family transposase -
JFL57_RS07730 1722321..1722581 + 261 Protein_1493 hemophilus-specific protein -
JFL57_RS07735 1722713..1722967 + 255 WP_075294104.1 DUF4160 domain-containing protein -
JFL57_RS07740 1722936..1723238 + 303 WP_075294105.1 DUF2442 domain-containing protein -
JFL57_RS07745 1723917..1724384 - 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
JFL57_RS07750 1724386..1724649 - 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFL57_RS07755 1724787..1725098 - 312 WP_075294107.1 hypothetical protein -
JFL57_RS07760 1725098..1725352 - 255 WP_198986875.1 DUF1778 domain-containing protein -
JFL57_RS07765 1725506..1726162 - 657 WP_157665518.1 hypothetical protein -
JFL57_RS07770 1726828..1729116 - 2289 WP_198986876.1 hypothetical protein -
JFL57_RS07775 1729179..1729541 - 363 WP_135026582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1721828..1722244 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T184696 WP_075294106.1 NZ_CP066565:c1724384-1723917 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T184696 NZ_CP087781:c1449765-1449583 [Moraxella bovis]
ATGAAGTATTCAGAGTTTCAAAGGTGGCTATTGGCACAAGGGGCAACGGTAAACAAGCAAGGCGGTAAAGGCTCGCACCG
TAAAGTTACCCTAAATGGCAAAACCACCACTTTCCCTTATCACGGCAGTAAAGAGATTGGGGAAGGACTAAGAAAGAAAA
TTTTAAAAGACTTGGATTTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184696 WP_011609927.1 NZ_CP066565:c1724649-1724386 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184696 NZ_CP087781:c1449521-1449108 [Moraxella bovis]
ATGTACTATCCTGCTACTTTTACCCCTGATACCAATGATACTTTTTTGGTGGCGTTTCGTGATATTCCCGAAGCGGTGGG
CGTGGGTGAAACCTTTGAAATCGCCTACCAATCCGCCCTTGACGGCTTAGAAACGGCATTTAGCATCTATATGGACGAAC
GCAAGCCAATCCCCGCCCCCAGTGAGCTGTCTGACGGCGAACACGCCATTTATTTGCCTGTGGCGGTACAGACCAAACTT
GCCTTATATCACGAAATGCTAGCCCAAGGCGTTACTAAGGCGGAGCTGGCTCGCCGTCTGTCTGTCAATCAAAAACAAAT
TGATAGACTTTGGGACGTGAGCCACTCCACCAAATTAGAATTTTTGGAAAAGGCGTTTAGCGTGCTAGGCAAACGCCTAT
CCCTAGCCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References