Detailed information of TA system TA184695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1359234..1359833
• Replicon: chromosome
• Accession: NZ_CP066565
• Organism: Histophilus somni strain ASc-MMNZ-VFA-076

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: JFL57_RS05935
• Protein ID: WP_012340732.1
• Coordinates: 1359234..1359539 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL57_RS05940
• Protein ID: WP_075294500.1
• Coordinates: 1359543..1359833 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL57_RS05915	1354584..1355444	+	861	WP_198986840.1	RNase adapter RapZ	-
JFL57_RS05920	1355480..1357531	-	2052	WP_198986841.1	methionine--tRNA ligase	-
JFL57_RS05925	1357672..1358793	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
JFL57_RS05930	1358777..1359013	-	237	WP_080514392.1	recombinase family protein	-
JFL57_RS05935	1359234..1359539	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
JFL57_RS05940	1359543..1359833	-	291	WP_075294500.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFL57_RS05945	1360005..1360568	-	564	WP_178384292.1	molecular chaperone	-
JFL57_RS05950	1360565..1361185	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
JFL57_RS05955	1361195..1361638	-	444	WP_012340735.1	NfeD family protein	-
JFL57_RS05960	1361685..1362605	-	921	WP_198986842.1	SPFH/Band 7/PHB domain protein	-
JFL57_RS05965	1362888..1363340	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
JFL57_RS05970	1363529..1363990	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / floR / tet(H)	luxS	1331689..1492990	161301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T184695 WP_012340732.1 NZ_CP066565:c1359539-1359234 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T184695 NZ_CP087781:1306463-1306720 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10832.18 Da
• Isoelectric Point: 4.2845

>AT184695 WP_075294500.1 NZ_CP066565:c1359833-1359543 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLVQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT184695 NZ_CP087781:1306231-1306473 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Structures

Toxin

• AlphaFold DB: B0UV74