Detailed information of TA system TA184694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 485302..485783
• Replicon: chromosome
• Accession: NZ_CP066565
• Organism: Histophilus somni strain ASc-MMNZ-VFA-076

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL57_RS02260
• Protein ID: WP_075294307.1
• Coordinates: 485302..485562 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL57_RS02265
• Protein ID: WP_075294306.1
• Coordinates: 485562..485783 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL57_RS02235	481357..482697	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
JFL57_RS02240	482763..483182	+	420	WP_075294310.1	pseudouridine synthase	-
JFL57_RS02245	483361..483552	+	192	WP_075294309.1	hypothetical protein	-
JFL57_RS02250	483668..485023	+	1356	WP_198986987.1	DUF560 domain-containing protein	-
JFL57_RS02255	485188..485298	+	111	Protein_434	CAAX protease	-
JFL57_RS02260	485302..485562	-	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL57_RS02265	485562..485783	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
JFL57_RS02270	486219..488141	+	1923	WP_198986988.1	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	467518..496309	28791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T184694 WP_075294307.1 NZ_CP066565:c485562-485302 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184694 NZ_CP087781:1306231-1306473 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT184694 WP_075294306.1 NZ_CP066565:c485783-485562 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184694 NZ_CP087781:1306463-1306720 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA