Detailed information of TA system TA184692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1359189..1359788
• Replicon: chromosome
• Accession: NZ_CP066564
• Organism: Histophilus somni strain ASc-MMNZ-VFA-69

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: JFL55_RS06145
• Protein ID: WP_012340732.1
• Coordinates: 1359189..1359494 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UV75
• Locus tag: JFL55_RS06150
• Protein ID: WP_012340733.1
• Coordinates: 1359498..1359788 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL55_RS06125	1354539..1355399	+	861	WP_011609333.1	RNase adapter RapZ	-
JFL55_RS06130	1355435..1357486	-	2052	WP_012340730.1	methionine--tRNA ligase	-
JFL55_RS06135	1357627..1358748	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
JFL55_RS06140	1358732..1358968	-	237	WP_080514392.1	recombinase family protein	-
JFL55_RS06145	1359189..1359494	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
JFL55_RS06150	1359498..1359788	-	291	WP_012340733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFL55_RS06155	1359960..1360523	-	564	WP_178384292.1	molecular chaperone	-
JFL55_RS06160	1360520..1361140	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
JFL55_RS06165	1361150..1361593	-	444	WP_012340735.1	NfeD family protein	-
JFL55_RS06170	1361640..1362560	-	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
JFL55_RS06175	1362843..1363295	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
JFL55_RS06180	1363484..1363945	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / floR	luxS	1334311..1486868	152557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T184692 WP_012340732.1 NZ_CP066564:c1359494-1359189 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T184692 NZ_CP087781:c1060430-1060152 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10804.13 Da
• Isoelectric Point: 4.2845

>AT184692 WP_012340733.1 NZ_CP066564:c1359788-1359498 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT184692 NZ_CP087781:c1060137-1059832 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Structures

Toxin

• AlphaFold DB: B0UV74

Antitoxin

• AlphaFold DB: B0UV75