Detailed information of TA system TA184691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1171691..1172249
• Replicon: chromosome
• Accession: NZ_CP066564
• Organism: Histophilus somni strain ASc-MMNZ-VFA-69

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UUG7
• Locus tag: JFL55_RS05330
• Protein ID: WP_012340589.1
• Coordinates: 1171977..1172249 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UUG6
• Locus tag: JFL55_RS05325
• Protein ID: WP_012340588.1
• Coordinates: 1171691..1171984 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL55_RS05295	1167937..1168626	-	690	WP_075293923.1	CidB/LrgB family autolysis modulator	-
JFL55_RS05300	1168623..1169039	-	417	WP_198974053.1	CidA/LrgA family protein	-
JFL55_RS05305	1169163..1169666	+	504	WP_012340583.1	thermonuclease family protein	-
JFL55_RS05310	1169656..1170855	+	1200	WP_012340584.1	cysteine desulfurase	-
JFL55_RS05315	1170852..1171220	+	369	WP_198974054.1	SufE family protein	-
JFL55_RS05320	1171278..1171415	-	138	WP_198974055.1	hypothetical protein	-
JFL55_RS05325	1171691..1171984	+	294	WP_012340588.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFL55_RS05330	1171977..1172249	+	273	WP_012340589.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JFL55_RS05335	1172334..1173476	-	1143	WP_075290626.1	porin	-
JFL55_RS05340	1173914..1174195	+	282	WP_012340591.1	virulence factor	-
JFL55_RS05345	1174394..1174693	+	300	WP_012340592.1	DUF1778 domain-containing protein	-
JFL55_RS05350	1174683..1175189	+	507	WP_012340594.1	GNAT family N-acetyltransferase	-
JFL55_RS05355	1175213..1176409	-	1197	WP_012340595.1	lipopolysaccharide assembly protein LapB	-
JFL55_RS05360	1176419..1176703	-	285	WP_012340596.1	DUF1049 domain-containing protein	-
JFL55_RS05365	1176823..1177107	-	285	WP_011609129.1	integration host factor subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10472.11 Da
• Isoelectric Point: 6.9669

>T184691 WP_012340589.1 NZ_CP066564:1171977-1172249 [Histophilus somni]
MAKRKFDMAKSFKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVDDVVELH
YLDSHSEIFG

Nucleotide

• Length: 273 bp

>T184691 NZ_CP087781:892187-892522 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11279.60 Da
• Isoelectric Point: 4.7815

>AT184691 WP_012340588.1 NZ_CP066564:1171691-1171984 [Histophilus somni]
MDYTNFNMRLDNDLRGRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FYSLDELNQAIKEISHG

Nucleotide

• Length: 294 bp

>AT184691 NZ_CP087781:891945-892187 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Structures

Toxin

• AlphaFold DB: B0UUG7

Antitoxin

• AlphaFold DB: B0UUG6