Detailed information of TA system TA184689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1573775..1574256
• Replicon: chromosome
• Accession: NZ_CP066563
• Organism: Histophilus somni strain ASc-MMNZ-VFA-075

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL54_RS07680
• Protein ID: WP_165942816.1
• Coordinates: 1573996..1574256 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL54_RS07675
• Protein ID: WP_011608602.1
• Coordinates: 1573775..1573996 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL54_RS07665	1571813..1573338	-	1526	Protein_1480	transferrin-binding protein-like solute binding protein	-
JFL54_RS07670	1573614..1573712	-	99	Protein_1481	IS200/IS605 family transposase	-
JFL54_RS07675	1573775..1573996	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFL54_RS07680	1573996..1574256	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL54_RS07685	1574435..1575892	-	1458	WP_132994700.1	DUF560 domain-containing protein	-
JFL54_RS07690	1576377..1576796	-	420	WP_075321652.1	pseudouridine synthase	-
JFL54_RS07695	1576862..1578202	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1568696..1579551	10855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T184689 WP_165942816.1 NZ_CP066563:1573996-1574256 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184689 NZ_CP087781:516272-516664 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184689 WP_011608602.1 NZ_CP066563:1573775-1573996 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184689 NZ_CP087781:516012-516275 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA