Detailed information of TA system TA184686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1580861..1581342
• Replicon: chromosome
• Accession: NZ_CP066562
• Organism: Histophilus somni strain ASc-MMNZ-VFA-074

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL53_RS07740
• Protein ID: WP_165942816.1
• Coordinates: 1581082..1581342 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL53_RS07735
• Protein ID: WP_011608602.1
• Coordinates: 1580861..1581082 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL53_RS07725	1578917..1580424	-	1508	Protein_1492	transferrin-binding protein-like solute binding protein	-
JFL53_RS07730	1580700..1580798	-	99	Protein_1493	IS200/IS605 family transposase	-
JFL53_RS07735	1580861..1581082	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFL53_RS07740	1581082..1581342	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL53_RS07745	1581521..1582978	-	1458	WP_132994700.1	DUF560 domain-containing protein	-
JFL53_RS07750	1583463..1583882	-	420	WP_075321652.1	pseudouridine synthase	-
JFL53_RS07755	1583948..1585288	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1577592..1586259	8667

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T184686 WP_165942816.1 NZ_CP066562:1581082-1581342 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184686 NZ_CP087771:c2264944-2264756 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184686 WP_011608602.1 NZ_CP066562:1580861-1581082 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184686 NZ_CP087771:c2264693-2264286 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG