Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 439940..440577 Replicon chromosome
Accession NZ_CP066562
Organism Histophilus somni strain ASc-MMNZ-VFA-074

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JFL53_RS02315 Protein ID WP_011609928.1
Coordinates 439940..440176 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFL53_RS02320 Protein ID WP_011609927.1
Coordinates 440314..440577 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL53_RS02300 435217..436569 + 1353 WP_198973741.1 hemagglutinin repeat-containing protein -
JFL53_RS02305 436572..438839 + 2268 WP_198973742.1 hypothetical protein -
JFL53_RS02310 439595..439864 + 270 WP_011609929.1 DUF1778 domain-containing protein -
JFL53_RS02315 439940..440176 + 237 WP_011609928.1 hypothetical protein Toxin
JFL53_RS02320 440314..440577 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFL53_RS02325 440579..441046 + 468 WP_011609926.1 GNAT family N-acetyltransferase -
JFL53_RS02330 441810..442070 - 261 Protein_449 hemophilus-specific protein -
JFL53_RS02335 442157..442603 - 447 WP_011609888.1 hypothetical protein -
JFL53_RS02340 442821..443153 - 333 WP_011609887.1 hypothetical protein -
JFL53_RS02345 443306..443443 - 138 WP_157856877.1 hypothetical protein -
JFL53_RS02350 443524..444171 - 648 WP_011609885.1 DUF3560 domain-containing protein -
JFL53_RS02355 444344..444637 - 294 WP_165942798.1 hypothetical protein -
JFL53_RS02360 444650..445105 - 456 WP_198973743.1 heme utilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8873.59 Da        Isoelectric Point: 10.4575

>T184684 WP_011609928.1 NZ_CP066562:439940-440176 [Histophilus somni]
MNLYLQKQVSQDIKRRIAPCFTVIDENKRILGYYTLASTSIPLVSLPENLKKKLPRYPSVPAVLLGRLAVDKQVSIFI

Download         Length: 237 bp

>T184684 NZ_CP087771:c1998329-1997994 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184684 WP_011609927.1 NZ_CP066562:440314-440577 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184684 NZ_CP087771:c1998571-1998329 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References