Detailed information of TA system TA184683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1700669..1701150
• Replicon: chromosome
• Accession: NZ_CP066559
• Organism: Histophilus somni strain ASc-MMNZ-VFA-071

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL50_RS08025
• Protein ID: WP_165942816.1
• Coordinates: 1700890..1701150 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL50_RS08020
• Protein ID: WP_011608602.1
• Coordinates: 1700669..1700890 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL50_RS08010	1698325..1700233	-	1909	Protein_1549	transferrin-binding protein-like solute binding protein	-
JFL50_RS08015	1700508..1700606	-	99	Protein_1550	IS200/IS605 family transposase	-
JFL50_RS08020	1700669..1700890	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFL50_RS08025	1700890..1701150	+	261	WP_165942816.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL50_RS08030	1701329..1701589	-	261	WP_198973542.1	DUF560 domain-containing protein	-
JFL50_RS08035	1701550..1702788	-	1239	WP_198973425.1	DUF560 domain-containing protein	-
JFL50_RS08040	1703273..1703692	-	420	WP_075321652.1	pseudouridine synthase	-
JFL50_RS08045	1703758..1705098	-	1341	WP_075321653.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10128.82 Da
• Isoelectric Point: 10.1365

>T184683 WP_165942816.1 NZ_CP066559:1700890-1701150 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTRNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184683 NZ_CP087771:1824528-1824806 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184683 WP_011608602.1 NZ_CP066559:1700669-1700890 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184683 NZ_CP087771:1824821-1825126 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA