Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 461673..462405 Replicon chromosome
Accession NZ_CP066559
Organism Histophilus somni strain ASc-MMNZ-VFA-071

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JFL50_RS02380 Protein ID WP_075294106.1
Coordinates 461938..462405 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFL50_RS02375 Protein ID WP_011609927.1
Coordinates 461673..461936 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL50_RS02350 456779..457141 + 363 WP_135026582.1 hypothetical protein -
JFL50_RS02355 457216..459489 + 2274 WP_132995746.1 hypothetical protein -
JFL50_RS02360 460160..460816 + 657 WP_157665518.1 hypothetical protein -
JFL50_RS02365 460970..461224 + 255 WP_075294108.1 DUF1778 domain-containing protein -
JFL50_RS02370 461224..461535 + 312 WP_075294107.1 hypothetical protein -
JFL50_RS02375 461673..461936 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFL50_RS02380 461938..462405 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
JFL50_RS02385 463084..463386 - 303 WP_075294105.1 DUF2442 domain-containing protein -
JFL50_RS02390 463355..463609 - 255 WP_075294104.1 DUF4160 domain-containing protein -
JFL50_RS02395 463741..464001 - 261 Protein_462 hemophilus-specific protein -
JFL50_RS02400 464078..464494 - 417 WP_075319814.1 IS200/IS605 family transposase -
JFL50_RS02405 464541..465677 + 1137 WP_075319813.1 transposase -
JFL50_RS02410 465933..466862 + 930 WP_075293400.1 hypothetical protein -
JFL50_RS02415 466881..467327 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 464078..464494 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T184682 WP_075294106.1 NZ_CP066559:461938-462405 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T184682 NZ_CP087771:1785077-1785355 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184682 WP_011609927.1 NZ_CP066559:461673-461936 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184682 NZ_CP087771:1785342-1785629 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References