Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 461697..462429 Replicon chromosome
Accession NZ_CP066558
Organism Histophilus somni strain ASc-MMNZ-VFA-070

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JFL49_RS02350 Protein ID WP_075294106.1
Coordinates 461962..462429 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFL49_RS02345 Protein ID WP_011609927.1
Coordinates 461697..461960 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL49_RS02320 456805..457167 + 363 WP_135026582.1 hypothetical protein -
JFL49_RS02325 457230..459518 + 2289 WP_075321885.1 hypothetical protein -
JFL49_RS02330 460184..460840 + 657 WP_157665518.1 hypothetical protein -
JFL49_RS02335 460994..461248 + 255 WP_075294108.1 DUF1778 domain-containing protein -
JFL49_RS02340 461248..461559 + 312 WP_075294107.1 hypothetical protein -
JFL49_RS02345 461697..461960 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFL49_RS02350 461962..462429 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
JFL49_RS02355 463108..463410 - 303 WP_075294105.1 DUF2442 domain-containing protein -
JFL49_RS02360 463379..463633 - 255 WP_075294104.1 DUF4160 domain-containing protein -
JFL49_RS02365 463765..464025 - 261 Protein_456 hemophilus-specific protein -
JFL49_RS02370 464102..464518 - 417 WP_075319814.1 IS200/IS605 family transposase -
JFL49_RS02375 464565..465701 + 1137 WP_075319813.1 transposase -
JFL49_RS02380 465957..466886 + 930 WP_075293400.1 hypothetical protein -
JFL49_RS02385 466905..467351 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 464102..464518 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T184679 WP_075294106.1 NZ_CP066558:461962-462429 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T184679 NZ_CP087771:c738573-738346 [Moraxella bovis]
ATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCAAGTCATGGTTTTTCATCGCCCACACCCAAGCCC
AAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATGGCATGGGTATCACACCATTAGATGACGACAGCC
AAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACTCATGAACACAATGACAATTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184679 WP_011609927.1 NZ_CP066558:461697-461960 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184679 NZ_CP087771:c738365-738030 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References