Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 241861..242387 Replicon plasmid pOSUCZ140_1
Accession NZ_CP066554
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JFN83_RS24820 Protein ID WP_000323025.1
Coordinates 242100..242387 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JFN83_RS24815 Protein ID WP_000534858.1
Coordinates 241861..242100 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFN83_RS24795 (JFN83_24675) 238189..239427 + 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -
JFN83_RS24800 (JFN83_24680) 239903..240475 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
JFN83_RS24805 (JFN83_24685) 240675..241598 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
JFN83_RS24810 241732..241836 - 105 Protein_238 protein YdfV -
JFN83_RS24815 (JFN83_24690) 241861..242100 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JFN83_RS24820 (JFN83_24695) 242100..242387 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JFN83_RS24825 (JFN83_24700) 242459..242617 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
JFN83_RS24830 (JFN83_24705) 243226..243546 - 321 WP_000332796.1 hypothetical protein -
JFN83_RS24835 (JFN83_24710) 243828..244031 - 204 WP_001015183.1 hypothetical protein -
JFN83_RS24840 (JFN83_24715) 244078..244428 - 351 WP_000743059.1 hypothetical protein -
JFN83_RS24845 (JFN83_24720) 244488..245090 - 603 WP_012695474.1 hypothetical protein -
JFN83_RS24850 (JFN83_24725) 245186..246130 - 945 WP_000778029.1 DUF5417 domain-containing protein -
JFN83_RS24855 (JFN83_24730) 246641..246817 + 177 WP_001371930.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-4 / mcr-9 - 1..266565 266565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T184677 WP_000323025.1 NZ_CP066554:242100-242387 [Enterobacter hormaechei subsp. xiangfangensis]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T184677 NZ_CP087771:497830-498102 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT184677 WP_000534858.1 NZ_CP066554:241861-242100 [Enterobacter hormaechei subsp. xiangfangensis]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT184677 NZ_CP087771:497544-497837 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACTCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References