Detailed information of TA system TA184676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 4443183..4443779
• Replicon: chromosome
• Accession: NZ_CP066553
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A837F9W8
• Locus tag: JFN83_RS21780
• Protein ID: WP_023315213.1
• Coordinates: 4443477..4443779 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: JFN83_RS21775
• Protein ID: WP_032610152.1
• Coordinates: 4443183..4443470 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFN83_RS21770 (JFN83_21670)	4441555..4443186	+	1632	WP_032610151.1	Na/Pi cotransporter family protein	-
JFN83_RS21775 (JFN83_21675)	4443183..4443470	-	288	WP_032610152.1	putative addiction module antidote protein	Antitoxin
JFN83_RS21780 (JFN83_21680)	4443477..4443779	-	303	WP_023315213.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFN83_RS21785 (JFN83_21685)	4443977..4444849	+	873	WP_003860347.1	23S rRNA pseudouridine(2604) synthase RluF	-
JFN83_RS21790 (JFN83_21690)	4444850..4445122	-	273	WP_003860346.1	DUF3811 domain-containing protein	-
JFN83_RS21795 (JFN83_21695)	4445173..4446117	-	945	WP_115877045.1	ketopantoate/pantoate/pantothenate transporter PanS	-
JFN83_RS21800 (JFN83_21700)	4446211..4447560	-	1350	WP_032608241.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-93)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11427.21 Da
• Isoelectric Point: 10.1042

>T184676 WP_023315213.1 NZ_CP066553:c4443779-4443477 [Enterobacter hormaechei subsp. xiangfangensis]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Nucleotide

• Length: 303 bp

>T184676 NZ_CP087771:c100212-99877 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10072.60 Da
• Isoelectric Point: 5.7807

>AT184676 WP_032610152.1 NZ_CP066553:c4443470-4443183 [Enterobacter hormaechei subsp. xiangfangensis]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISLQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Nucleotide

• Length: 288 bp

>AT184676 NZ_CP087771:c99887-99606 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Structures

Toxin

• AlphaFold DB: A0A837F9W8