Detailed information of TA system TA184675

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3934213..3934820
• Replicon: chromosome
• Accession: NZ_CP066553
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: JFN83_RS19395
• Protein ID: WP_057979982.1
• Coordinates: 3934635..3934820 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JFN83_RS19390
• Protein ID: WP_023315016.1
• Coordinates: 3934213..3934620 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFN83_RS19375 (JFN83_19280)	3930956..3932209	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
JFN83_RS19380 (JFN83_19285)	3932217..3932672	-	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
JFN83_RS19385 (JFN83_19290)	3933133..3934209	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
JFN83_RS19390 (JFN83_19295)	3934213..3934620	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JFN83_RS19395 (JFN83_19300)	3934635..3934820	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
JFN83_RS19400 (JFN83_19305)	3935070..3936608	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
JFN83_RS19405 (JFN83_19310)	3936775..3937659	+	885	WP_003860164.1	ROK family protein	-
JFN83_RS19410 (JFN83_19315)	3937663..3939501	-	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T184675 WP_057979982.1 NZ_CP066553:c3934820-3934635 [Enterobacter hormaechei subsp. xiangfangensis]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T184675 NZ_CP087768:c2285593-2285405 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT184675 WP_023315016.1 NZ_CP066553:c3934620-3934213 [Enterobacter hormaechei subsp. xiangfangensis]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT184675 NZ_CP087768:c2285342-2284935 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0