Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 3466064..3466743 | Replicon | chromosome |
| Accession | NZ_CP066553 | ||
| Organism | Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | JFN83_RS17090 | Protein ID | WP_032608412.1 |
| Coordinates | 3466064..3466405 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | JFN83_RS17095 | Protein ID | WP_020456353.1 |
| Coordinates | 3466426..3466743 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFN83_RS17055 (JFN83_16965) | 3461557..3461808 | + | 252 | WP_032608418.1 | hypothetical protein | - |
| JFN83_RS17060 (JFN83_16970) | 3461881..3462105 | + | 225 | WP_032608417.1 | colicin E3-like toxin immunity protein | - |
| JFN83_RS17065 (JFN83_16975) | 3462164..3462412 | + | 249 | WP_032608415.1 | bacteriocin immunity protein | - |
| JFN83_RS17070 (JFN83_16980) | 3462527..3462898 | + | 372 | WP_032608414.1 | hypothetical protein | - |
| JFN83_RS17075 (JFN83_16985) | 3462978..3463451 | - | 474 | WP_072163380.1 | SymE family type I addiction module toxin | - |
| JFN83_RS17080 (JFN83_16990) | 3463752..3464621 | + | 870 | WP_032608413.1 | HNH endonuclease | - |
| JFN83_RS17085 (JFN83_16995) | 3464802..3465809 | - | 1008 | WP_020456355.1 | restriction endonuclease | - |
| JFN83_RS17090 (JFN83_17000) | 3466064..3466405 | - | 342 | WP_032608412.1 | TA system toxin CbtA family protein | Toxin |
| JFN83_RS17095 (JFN83_17005) | 3466426..3466743 | - | 318 | WP_020456353.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JFN83_RS17100 (JFN83_17010) | 3466761..3466982 | - | 222 | WP_032608411.1 | DUF987 domain-containing protein | - |
| JFN83_RS17105 (JFN83_17015) | 3466991..3467470 | - | 480 | WP_020456351.1 | DNA repair protein RadC | - |
| JFN83_RS17110 (JFN83_17020) | 3467513..3467731 | - | 219 | WP_020456350.1 | hypothetical protein | - |
| JFN83_RS17115 (JFN83_17025) | 3467741..3468199 | - | 459 | WP_032608410.1 | antirestriction protein | - |
| JFN83_RS17120 (JFN83_17030) | 3468305..3468505 | - | 201 | WP_050596949.1 | DUF905 family protein | - |
| JFN83_RS17125 (JFN83_17035) | 3468633..3469499 | - | 867 | WP_032608409.1 | hypothetical protein | - |
| JFN83_RS26085 | 3469563..3469685 | - | 123 | WP_020456347.1 | hypothetical protein | - |
| JFN83_RS17130 (JFN83_17040) | 3469738..3470421 | - | 684 | WP_020456346.1 | DeoR family transcriptional regulator | - |
| JFN83_RS17135 (JFN83_17045) | 3470630..3471454 | - | 825 | Protein_3369 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA | - | 3456659..3496165 | 39506 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12747.73 Da Isoelectric Point: 9.0060
>T184674 WP_032608412.1 NZ_CP066553:c3466405-3466064 [Enterobacter hormaechei subsp. xiangfangensis]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T184674 NZ_CP087768:c2124911-2124510 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11846.39 Da Isoelectric Point: 5.5403
>AT184674 WP_020456353.1 NZ_CP066553:c3466743-3466426 [Enterobacter hormaechei subsp. xiangfangensis]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 318 bp
>AT184674 NZ_CP087768:c2125159-2124926 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|