Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2946225..2946845 Replicon chromosome
Accession NZ_CP066553
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag JFN83_RS14675 Protein ID WP_015571250.1
Coordinates 2946627..2946845 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag JFN83_RS14670 Protein ID WP_006809850.1
Coordinates 2946225..2946599 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFN83_RS14660 (JFN83_14570) 2941352..2942545 + 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JFN83_RS14665 (JFN83_14575) 2942568..2945714 + 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
JFN83_RS14670 (JFN83_14580) 2946225..2946599 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
JFN83_RS14675 (JFN83_14585) 2946627..2946845 + 219 WP_015571250.1 HHA domain-containing protein Toxin
JFN83_RS14680 (JFN83_14590) 2947054..2947605 + 552 WP_022650496.1 maltose O-acetyltransferase -
JFN83_RS14685 (JFN83_14595) 2947722..2948189 + 468 WP_022650495.1 YlaC family protein -
JFN83_RS14690 (JFN83_14600) 2948161..2949621 - 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
JFN83_RS14695 (JFN83_14605) 2949723..2950433 + 711 WP_022650493.1 GNAT family protein -
JFN83_RS14700 (JFN83_14610) 2950430..2950570 - 141 WP_032608666.1 type B 50S ribosomal protein L36 -
JFN83_RS14705 (JFN83_14615) 2950573..2950833 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T184673 WP_015571250.1 NZ_CP066553:2946627-2946845 [Enterobacter hormaechei subsp. xiangfangensis]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T184673 NZ_CP087768:c2020168-2019833 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT184673 WP_006809850.1 NZ_CP066553:2946225-2946599 [Enterobacter hormaechei subsp. xiangfangensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT184673 NZ_CP087768:c2020410-2020168 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References