Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1696212..1696951 Replicon chromosome
Accession NZ_CP066553
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag JFN83_RS08420 Protein ID WP_032609220.1
Coordinates 1696466..1696951 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JFN83_RS08415 Protein ID WP_003857131.1
Coordinates 1696212..1696478 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFN83_RS08395 (JFN83_08330) 1691688..1692674 + 987 WP_003857123.1 DUF979 domain-containing protein -
JFN83_RS08400 (JFN83_08335) 1692684..1693679 + 996 WP_032666403.1 DUF2891 domain-containing protein -
JFN83_RS08405 (JFN83_08340) 1693701..1695089 - 1389 WP_032609222.1 MFS transporter -
JFN83_RS08410 (JFN83_08345) 1695219..1696148 + 930 WP_032609221.1 LysR family transcriptional regulator -
JFN83_RS08415 (JFN83_08350) 1696212..1696478 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JFN83_RS08420 (JFN83_08355) 1696466..1696951 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
JFN83_RS08425 (JFN83_08360) 1697129..1698421 - 1293 WP_032609218.1 glycosyl hydrolase family 28 protein -
JFN83_RS08430 (JFN83_08365) 1698526..1699284 - 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
JFN83_RS08435 (JFN83_08370) 1699371..1699955 + 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
JFN83_RS08440 (JFN83_08375) 1700040..1700798 + 759 WP_023314159.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T184672 WP_032609220.1 NZ_CP066553:1696466-1696951 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T184672 NZ_CP087768:1837713-1837991 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT184672 WP_003857131.1 NZ_CP066553:1696212-1696478 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT184672 NZ_CP087768:1838006-1838311 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References