Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA(toxin) |
| Location | 890070..891853 | Replicon | chromosome |
| Accession | NZ_CP066553 | ||
| Organism | Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | JFN83_RS04445 | Protein ID | WP_032609694.1 |
| Coordinates | 890504..891853 (-) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A837FFV9 |
| Locus tag | JFN83_RS04440 | Protein ID | WP_003859317.1 |
| Coordinates | 890070..890507 (-) | Length | 146 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFN83_RS04420 (JFN83_04385) | 885089..886111 | + | 1023 | WP_003859324.1 | HTH-type transcriptional regulator GalS | - |
| JFN83_RS04425 (JFN83_04390) | 886407..887405 | + | 999 | WP_003859322.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| JFN83_RS04430 (JFN83_04395) | 887485..889005 | + | 1521 | WP_003859320.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| JFN83_RS04435 (JFN83_04400) | 889021..890031 | + | 1011 | WP_003859318.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| JFN83_RS04440 (JFN83_04405) | 890070..890507 | - | 438 | WP_003859317.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| JFN83_RS04445 (JFN83_04410) | 890504..891853 | - | 1350 | WP_032609694.1 | HipA domain-containing protein | Toxin |
| JFN83_RS04450 (JFN83_04415) | 891988..892698 | - | 711 | WP_003859314.1 | outer membrane permeability protein SanA | - |
| JFN83_RS04455 (JFN83_04420) | 892826..893710 | - | 885 | WP_032609693.1 | cytidine deaminase | - |
| JFN83_RS04460 (JFN83_04425) | 893839..894534 | - | 696 | WP_003859310.1 | CidB/LrgB family autolysis modulator | - |
| JFN83_RS04465 (JFN83_04430) | 894531..894926 | - | 396 | WP_003859308.1 | CidA/LrgA family protein | - |
| JFN83_RS04470 (JFN83_04435) | 895095..896030 | + | 936 | WP_003859306.1 | tRNA dihydrouridine(16) synthase DusC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51149.84 Da Isoelectric Point: 4.6562
>T184665 WP_032609694.1 NZ_CP066553:c891853-890504 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
Download Length: 1350 bp
>T184665 NZ_CP087768:c180844-180509 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA
Antitoxin
Download Length: 146 a.a. Molecular weight: 16185.64 Da Isoelectric Point: 10.5154
>AT184665 WP_003859317.1 NZ_CP066553:c890507-890070 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
Download Length: 438 bp
>AT184665 NZ_CP087768:c180519-180238 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|