Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 188662..189319 Replicon chromosome
Accession NZ_CP066553
Organism Enterobacter hormaechei subsp. xiangfangensis strain OSUCZKPC4-140

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JFN83_RS00975 Protein ID WP_022649305.1
Coordinates 188909..189319 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JFN83_RS00970 Protein ID WP_003863437.1
Coordinates 188662..188928 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFN83_RS00950 (JFN83_00945) 184094..185527 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
JFN83_RS00955 (JFN83_00950) 185644..186375 - 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
JFN83_RS00960 (JFN83_00955) 186642..187301 + 660 WP_003863433.1 hemolysin III family protein -
JFN83_RS00965 (JFN83_00960) 187387..188367 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JFN83_RS00970 (JFN83_00965) 188662..188928 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JFN83_RS00975 (JFN83_00970) 188909..189319 + 411 WP_022649305.1 protein YgfX Toxin
JFN83_RS00980 (JFN83_00975) 189321..189842 - 522 WP_003863440.1 flavodoxin FldB -
JFN83_RS00985 (JFN83_00980) 189944..190840 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JFN83_RS00990 (JFN83_00985) 190869..191582 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JFN83_RS00995 (JFN83_00990) 191588..193321 + 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T184664 WP_022649305.1 NZ_CP066553:188909-189319 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T184664 NZ_CP087765:2603769-2603957 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT184664 WP_003863437.1 NZ_CP066553:188662-188928 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT184664 NZ_CP087765:2604020-2604427 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References