Detailed information of TA system TA184663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4678241..4679784
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JFY74_RS20810
• Protein ID: WP_198997728.1
• Coordinates: 4678241..4679518 (-)
• Length: 426 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JFY74_RS20815
• Protein ID: WP_039475230.1
• Coordinates: 4679518..4679784 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS20785	4674339..4674479	+	141	WP_005976668.1	50S ribosomal protein L34	-
JFY74_RS20790	4674498..4674857	+	360	WP_010302382.1	ribonuclease P protein component	-
JFY74_RS20795	4674821..4675078	+	258	WP_010302384.1	membrane protein insertion efficiency factor YidD	-
JFY74_RS20800	4675081..4676715	+	1635	WP_198997726.1	membrane protein insertase YidC	-
JFY74_RS20805	4676844..4678208	+	1365	WP_198997727.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
JFY74_RS20810	4678241..4679518	-	1278	WP_198997728.1	type II toxin-antitoxin system HipA family toxin	Toxin
JFY74_RS20815	4679518..4679784	-	267	WP_039475230.1	helix-turn-helix domain-containing protein	Antitoxin
JFY74_RS20820	4679945..4680508	+	564	WP_198997729.1	hypothetical protein	-
JFY74_RS20825	4680565..4681416	-	852	WP_198997730.1	SDR family oxidoreductase	-
JFY74_RS20830	4681531..4681941	+	411	WP_198997731.1	helix-turn-helix transcriptional regulator	-
JFY74_RS20835	4681991..4682545	-	555	WP_039475220.1	TetR/AcrR family transcriptional regulator	-
JFY74_RS20840	4682649..4684138	+	1490	Protein_4061	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-388)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 426 a.a.
• Molecular weight: 47825.78 Da
• Isoelectric Point: 6.4403

>T184663 WP_198997728.1 NZ_CP066552:c4679518-4678241 [Pectobacterium carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSVPLRHQSYQGDEVYNFFDNLLPDNPDIRRRIVARYH
TDSTQPFDLLAKVGQDSVGALQLVPQGSPVHDIKKIEYKTLSEQQLENILTGYLYDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTVDNVITTVGSQLPVD
FPTHISEAILTGLLARSRRLMRGWE

Nucleotide

• Length: 1278 bp

>T184663 NZ_CP087765:2026082-2026417 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9917.18 Da
• Isoelectric Point: 9.7281

>AT184663 WP_039475230.1 NZ_CP066552:c4679784-4679518 [Pectobacterium carotovorum]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW

Nucleotide

• Length: 267 bp

>AT184663 NZ_CP087765:2026407-2026688 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA