Detailed information of TA system TA184662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4476155..4476772
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JFY74_RS19985
• Protein ID: WP_198997636.1
• Coordinates: 4476155..4476334 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A7T5QP09
• Locus tag: JFY74_RS19990
• Protein ID: WP_010299285.1
• Coordinates: 4476362..4476772 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS19960	4471391..4472551	-	1161	WP_198997633.1	cystathionine gamma-synthase	-
JFY74_RS19965	4472739..4473056	+	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
JFY74_RS19970	4473279..4474076	+	798	WP_198997634.1	ABC transporter ATP-binding protein	-
JFY74_RS19975	4474086..4475048	+	963	WP_198997635.1	ABC transporter substrate-binding protein	-
JFY74_RS19980	4475045..4476055	+	1011	Protein_3889	iron ABC transporter permease	-
JFY74_RS19985	4476155..4476334	+	180	WP_198997636.1	type II toxin-antitoxin system HicA family toxin	Toxin
JFY74_RS19990	4476362..4476772	+	411	WP_010299285.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JFY74_RS19995	4476870..4477085	-	216	WP_010281510.1	50S ribosomal protein L31	-
JFY74_RS20000	4477399..4479597	+	2199	WP_198997637.1	primosomal protein N'	-
JFY74_RS20005	4479889..4480932	+	1044	WP_198997638.1	DNA-binding transcriptional regulator CytR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6559.75 Da
• Isoelectric Point: 11.1589

>T184662 WP_198997636.1 NZ_CP066552:4476155-4476334 [Pectobacterium carotovorum]
MDSRTLIAEIKADGWKLIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T184662 NZ_CP087765:c1690795-1690523 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14549.41 Da
• Isoelectric Point: 4.3391

>AT184662 WP_010299285.1 NZ_CP066552:4476362-4476772 [Pectobacterium carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT184662 NZ_CP087765:c1691081-1690788 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACTCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A7T5QP09