Detailed information of TA system TA184658

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3280384..3281183
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: A0A7T5U992
• Locus tag: JFY74_RS14635
• Protein ID: WP_039535340.1
• Coordinates: 3280764..3281183 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: JFY74_RS14630
• Protein ID: WP_182813629.1
• Coordinates: 3280384..3280767 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS14615	3275590..3276726	-	1137	WP_198997098.1	polysaccharide export protein	-
JFY74_RS14620	3276844..3277941	-	1098	WP_198999113.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-
JFY74_RS14625	3278684..3280270	+	1587	WP_198997099.1	TerC family protein	-
JFY74_RS14630	3280384..3280767	+	384	WP_182813629.1	nucleotidyltransferase domain-containing protein	Antitoxin
JFY74_RS14635	3280764..3281183	+	420	WP_039535340.1	DUF86 domain-containing protein	Toxin
JFY74_RS14640	3281227..3282579	-	1353	WP_014914716.1	anaerobic C4-dicarboxylate transporter DcuC	-
JFY74_RS14645	3282842..3284677	-	1836	WP_198997100.1	outer membrane assembly protein AsmA	-
JFY74_RS14650	3284741..3285322	-	582	WP_005974037.1	dCTP deaminase	-
JFY74_RS14655	3285430..3286071	-	642	WP_039302211.1	uridine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (13-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (4-93)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16038.34 Da
• Isoelectric Point: 6.9682

>T184658 WP_039535340.1 NZ_CP066552:3280764-3281183 [Pectobacterium carotovorum]
MTDILLNKSSTIQRCLRRIREEFDTEEGFRQNFTKQDSVILNIQRACEAAIDIANYLIRIKQLGIPQSSRDSFALLAANQ
IITVDLSDNLQKMVGLRNIAVHDYQALNLDIVIHVISHRLSDFEHFIKQIARYSDSQHL

Nucleotide

• Length: 420 bp

>T184658 NZ_CP087765:560422-560679 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14342.59 Da
• Isoelectric Point: 4.9205

>AT184658 WP_182813629.1 NZ_CP066552:3280384-3280767 [Pectobacterium carotovorum]
MFDKIVLTLKKQMPDIKIIYLFGSQATGNARADSDIDIAIMATRALAPIERWELSNQLAKEVGHDVDLIDLLQASTVLKM
EIVRNGKLLYDAETAAGEFEMTTLSMYQHLQKERADIIRSFNQDLKA

Nucleotide

• Length: 384 bp

>AT184658 NZ_CP087765:560190-560432 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Structures

Toxin

• AlphaFold DB: A0A7T5U992