Detailed information of TA system TA184654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1440231..1440856
• Replicon: chromosome
• Accession: NZ_CP066552
• Organism: Pectobacterium carotovorum strain 2A

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: C6DB72
• Locus tag: JFY74_RS06385
• Protein ID: WP_005976087.1
• Coordinates: 1440231..1440434 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JFY74_RS06390
• Protein ID: WP_198998474.1
• Coordinates: 1440488..1440856 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY74_RS06355	1435688..1436026	+	339	WP_002208627.1	P-II family nitrogen regulator	-
JFY74_RS06360	1436066..1437352	+	1287	WP_198998470.1	ammonium transporter AmtB	-
JFY74_RS06365	1437487..1438350	-	864	WP_198998471.1	acyl-CoA thioesterase II	-
JFY74_RS06370	1438563..1439144	+	582	WP_198998472.1	YbaY family lipoprotein	-
JFY74_RS06375	1439164..1439484	-	321	WP_198998473.1	MGMT family protein	-
JFY74_RS06385	1440231..1440434	-	204	WP_005976087.1	hemolysin expression modulator Hha	Toxin
JFY74_RS06390	1440488..1440856	-	369	WP_198998474.1	Hha toxicity modulator TomB	Antitoxin
JFY74_RS06395	1441453..1441596	-	144	WP_005976091.1	type B 50S ribosomal protein L36	-
JFY74_RS06400	1441613..1441861	-	249	WP_039506474.1	type B 50S ribosomal protein L31	-
JFY74_RS06405	1442104..1445232	-	3129	WP_198998475.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8145.52 Da
• Isoelectric Point: 8.9008

>T184654 WP_005976087.1 NZ_CP066552:c1440434-1440231 [Pectobacterium carotovorum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Nucleotide

• Length: 204 bp

>T184654 NZ_CP087765:141818-142153 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14034.74 Da
• Isoelectric Point: 4.4787

>AT184654 WP_198998474.1 NZ_CP066552:c1440856-1440488 [Pectobacterium carotovorum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENTCTPAKT

Nucleotide

• Length: 369 bp

>AT184654 NZ_CP087765:141576-141818 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Structures

Toxin

• AlphaFold DB: A0A1D7Z3F0