Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1193309..1193922 | Replicon | chromosome |
| Accession | NZ_CP066546 | ||
| Organism | Pseudomonas chlororaphis subsp. aureofaciens strain SPS-41 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A285EYZ4 |
| Locus tag | JE032_RS05520 | Protein ID | WP_009041685.1 |
| Coordinates | 1193309..1193491 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A554PT90 |
| Locus tag | JE032_RS05525 | Protein ID | WP_009046450.1 |
| Coordinates | 1193521..1193922 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JE032_RS05495 | 1188493..1190457 | + | 1965 | WP_164485207.1 | choline transporter BetT | - |
| JE032_RS05500 | 1190570..1190827 | - | 258 | WP_103331255.1 | hypothetical protein | - |
| JE032_RS05505 | 1190880..1191368 | - | 489 | WP_028683850.1 | DoxX family protein | - |
| JE032_RS05510 | 1191425..1192165 | - | 741 | WP_009046448.1 | SDR family oxidoreductase | - |
| JE032_RS05515 | 1192294..1193184 | + | 891 | WP_009046449.1 | LysR family transcriptional regulator | - |
| JE032_RS05520 | 1193309..1193491 | + | 183 | WP_009041685.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| JE032_RS05525 | 1193521..1193922 | + | 402 | WP_009046450.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| JE032_RS05530 | 1194491..1195528 | + | 1038 | WP_198919623.1 | L-glyceraldehyde 3-phosphate reductase | - |
| JE032_RS05535 | 1195658..1196086 | - | 429 | WP_023970008.1 | type II toxin-antitoxin system VapC family toxin | - |
| JE032_RS05540 | 1196083..1196328 | - | 246 | WP_028683845.1 | plasmid stabilization protein | - |
| JE032_RS05545 | 1196468..1197307 | - | 840 | WP_101281653.1 | taurine dioxygenase | - |
| JE032_RS05550 | 1197534..1198373 | - | 840 | WP_009046455.1 | taurine ABC transporter permease TauC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.08 Da Isoelectric Point: 10.4588
>T184641 WP_009041685.1 NZ_CP066546:1193309-1193491 [Pseudomonas chlororaphis subsp. aureofaciens]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK
Download Length: 183 bp
>T184641 NZ_CP087715:c1934855-1934073 [Microbulbifer celer]
GTGATCGATCTGCGCGATACAATCCGCCTGTCGGCAACCCGCTTGATCGGCCGCCTGTATCGCATCATCGAGTCCCAGGA
AGAAGTCGCCACCAGAAGTCTGGTAGATAGCCTGCACAAGCAGGAGATCCTGGAAAACCTCCTTGAGCAAAGTAAGCCCG
CTCGCCTGCCGGGCAGCGAGCACCTGCACTACCTGCTGGCAACCCCGTTCCGCTATCCGCCATTGCCCTGGGGGTCCCGC
TTTGGCGGCACTGCCGAGAGTGGCATTTTCTACGGCAGCAAAAACGTTTCCACGGTTCTCTCCGAAGCCGCCTATTATCG
CCTGCTGTTTCTGAATGATATGGAGCAGGCGCCCGAAAAAGCGGTGACCAGCTATCACCAGATCTTTTCGGCGAAATATT
GTGCAGACCCTGGCGTTCGCCTGCAGGCTGAAGCATGGAAAGAACACTGGCCGGAACTGACGCATACATCCGAGTATCGA
TTCTGTCAGCACTTGGGAGCGCAAATGCGTGAGTGCAGTATTCAAGGCGTGGAAGCCCCCTCGGCCAGAGCACTGAGTGC
GGGTATTGCCAGCCTGCCCATCGACAGCTCCGAAGGCGTCAATGTCGCGCTGTTCGAGCCCCAGGCCCTGCTGCGCCGTC
CCCCGACAATCGAAGCGGAAGTGACCGCCGAATCTACCCCTGACAGCGTCTCCTTTCTGGTGAAGTCTGGGGACCGGGTG
GAAACCAAAAGCTTCGAGCGCTCTCAGTTTATGGCTGCGGGTAAACTACCTCAGCCCGCATAG
GTGATCGATCTGCGCGATACAATCCGCCTGTCGGCAACCCGCTTGATCGGCCGCCTGTATCGCATCATCGAGTCCCAGGA
AGAAGTCGCCACCAGAAGTCTGGTAGATAGCCTGCACAAGCAGGAGATCCTGGAAAACCTCCTTGAGCAAAGTAAGCCCG
CTCGCCTGCCGGGCAGCGAGCACCTGCACTACCTGCTGGCAACCCCGTTCCGCTATCCGCCATTGCCCTGGGGGTCCCGC
TTTGGCGGCACTGCCGAGAGTGGCATTTTCTACGGCAGCAAAAACGTTTCCACGGTTCTCTCCGAAGCCGCCTATTATCG
CCTGCTGTTTCTGAATGATATGGAGCAGGCGCCCGAAAAAGCGGTGACCAGCTATCACCAGATCTTTTCGGCGAAATATT
GTGCAGACCCTGGCGTTCGCCTGCAGGCTGAAGCATGGAAAGAACACTGGCCGGAACTGACGCATACATCCGAGTATCGA
TTCTGTCAGCACTTGGGAGCGCAAATGCGTGAGTGCAGTATTCAAGGCGTGGAAGCCCCCTCGGCCAGAGCACTGAGTGC
GGGTATTGCCAGCCTGCCCATCGACAGCTCCGAAGGCGTCAATGTCGCGCTGTTCGAGCCCCAGGCCCTGCTGCGCCGTC
CCCCGACAATCGAAGCGGAAGTGACCGCCGAATCTACCCCTGACAGCGTCTCCTTTCTGGTGAAGTCTGGGGACCGGGTG
GAAACCAAAAGCTTCGAGCGCTCTCAGTTTATGGCTGCGGGTAAACTACCTCAGCCCGCATAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14596.44 Da Isoelectric Point: 4.9133
>AT184641 WP_009046450.1 NZ_CP066546:1193521-1193922 [Pseudomonas chlororaphis subsp. aureofaciens]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
Download Length: 402 bp
>AT184641 NZ_CP087715:c1935214-1934852 [Microbulbifer celer]
ATGGCAAATCCAGCCCATACCCCTCAGGCCACTGAAGATCAGGTCCTGCTTGAGGCAACCCTCAATACCGCCCATCATCT
GGGCCTCAAGAAGAAAGAGCTCAGCGAAATCATCCACTTGGATGATCGCACCCTGCGTCGCCGCAACGGTCTCGCCCCGC
AAAGTGCTGAAGGCCAGCTTGCTCTTTTGCTGGTACGGGCCTACCGCGCGGCTTTTGTTCTTATGGGCGGAGAAGAGGGC
GCCAGGACCTGGTTTGCAACCGCCAATCGCGCACTGAACGGCGTGCCAAAAGAGTTGGCCCATCGCATTGATGGCCTGGT
ACGTATCGTCACTTACCTGGACGCCATGCGAGGTAAGGTGTGA
ATGGCAAATCCAGCCCATACCCCTCAGGCCACTGAAGATCAGGTCCTGCTTGAGGCAACCCTCAATACCGCCCATCATCT
GGGCCTCAAGAAGAAAGAGCTCAGCGAAATCATCCACTTGGATGATCGCACCCTGCGTCGCCGCAACGGTCTCGCCCCGC
AAAGTGCTGAAGGCCAGCTTGCTCTTTTGCTGGTACGGGCCTACCGCGCGGCTTTTGTTCTTATGGGCGGAGAAGAGGGC
GCCAGGACCTGGTTTGCAACCGCCAATCGCGCACTGAACGGCGTGCCAAAAGAGTTGGCCCATCGCATTGATGGCCTGGT
ACGTATCGTCACTTACCTGGACGCCATGCGAGGTAAGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A285EYZ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A554PT90 |