Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4174815..4175469 Replicon chromosome
Accession NZ_CP066543
Organism Klebsiella pneumoniae strain BTS

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag D6T75_RS21440 Protein ID WP_004144731.1
Coordinates 4174815..4175222 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag D6T75_RS21445 Protein ID WP_002916312.1
Coordinates 4175203..4175469 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6T75_RS21420 4170815..4172548 - 1734 WP_200302462.1 single-stranded-DNA-specific exonuclease RecJ -
D6T75_RS21425 4172554..4173267 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
D6T75_RS21430 4173290..4174186 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
D6T75_RS21435 4174287..4174808 + 522 WP_002916308.1 flavodoxin FldB -
D6T75_RS21440 4174815..4175222 - 408 WP_004144731.1 protein YgfX Toxin
D6T75_RS21445 4175203..4175469 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
D6T75_RS21450 4175715..4176698 + 984 WP_200302464.1 tRNA-modifying protein YgfZ -
D6T75_RS21455 4176849..4177508 - 660 WP_002916317.1 hemolysin III family protein -
D6T75_RS21460 4177672..4177983 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
D6T75_RS21465 4178033..4178761 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
D6T75_RS21470 4178880..4180313 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T184630 WP_004144731.1 NZ_CP066543:c4175222-4174815 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T184630 NZ_CP087706:c4598831-4598298 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATAAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT184630 WP_002916312.1 NZ_CP066543:c4175469-4175203 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT184630 NZ_CP087706:c4599108-4598842 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References