Detailed information of TA system TA184615

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1560919..1561531
• Replicon: chromosome
• Accession: NZ_CP066541
• Organism: Streptococcus pyogenes strain MGAS270

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JF649_RS07765
• Protein ID: WP_002994716.1
• Coordinates: 1561196..1561531 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: JF649_RS07760
• Protein ID: WP_002988079.1
• Coordinates: 1560919..1561206 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF649_RS07735 (JF649_07720)	1556110..1557093	-	984	WP_111702287.1	tagatose-bisphosphate aldolase	-
JF649_RS07740 (JF649_07725)	1557097..1558026	-	930	WP_115354284.1	tagatose-6-phosphate kinase	-
JF649_RS07745 (JF649_07730)	1558072..1558587	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
JF649_RS07750 (JF649_07735)	1558622..1559050	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
JF649_RS07755 (JF649_07740)	1559496..1560269	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
JF649_RS07760 (JF649_07745)	1560919..1561206	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
JF649_RS07765 (JF649_07750)	1561196..1561531	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JF649_RS07770	1561628..1562665	+	1038	Protein_1471	site-specific integrase	-
JF649_RS07775 (JF649_07765)	1562785..1563177	-	393	WP_002982716.1	30S ribosomal protein S9	-
JF649_RS07780 (JF649_07770)	1563198..1563644	-	447	WP_002982710.1	50S ribosomal protein L13	-
JF649_RS07785 (JF649_07775)	1563862..1564068	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
JF649_RS07790 (JF649_07780)	1564065..1564763	-	699	WP_021340943.1	hypothetical protein	-
JF649_RS07795 (JF649_07785)	1564899..1565759	-	861	WP_085634396.1	DegV family protein	-
JF649_RS07800 (JF649_07790)	1565856..1566374	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T184615 WP_002994716.1 NZ_CP066541:1561196-1561531 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T184615 NZ_CP087696:46558-46881 [Xylella taiwanensis]
ATGACTCAACGCGGCGACCTTGTAACGGTTTCCCTGCAAGGCGATTATGGCAAACCTAGACCGGCGTTAATCCTCCAATC
AGACCTGCTGATGGAGCTAGATAGTGTCGTACTGTGTCCGGTCACAAGTGAGCTACGTAATGCGATATTTCGCATCACCG
TTGAACCAAACATAGCCAATGGGCTACGGACGCTCTCGCAAATCATGGTAGACAAAATTTCAACACTGCCGCGTAGCAAA
ATCAGCAAACCTTTTGGACATCTCAATGACGAGAGGATAAAAGCAGTAGAAAAAGCACTGTTGCTCATCGTTGGTATCAT
CTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT184615 WP_002988079.1 NZ_CP066541:1560919-1561206 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT184615 NZ_CP087696:46340-46561 [Xylella taiwanensis]
ATGGCATTCATTCACGAACCGACTAGCAAAGTAGCTCGCCACCGAAAGCAAATGCGCGCAGCGGGATTACGTCCTGTCCA
GTTCTGGGTACCGGATACGCGCACACCGGAATTCGCCGCTGAAATTCGGAGCCAGTGCAGGAGCCTGAAGAACGACCCGG
AAGAAGCTGACGCTTTGCGCTTCACCGAAGAAGCCATAACCCATATTGAAGGCTGGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94