184612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 140420..141063 Replicon plasmid pKPC2_090374
Accession NZ_CP066536
Organism Klebsiella pneumoniae strain WCHKP090374

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag H3G96_RS28820 Protein ID WP_001044770.1
Coordinates 140647..141063 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag H3G96_RS28815 Protein ID WP_001261282.1
Coordinates 140420..140650 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G96_RS28780 135643..136422 - 780 WP_013214009.1 site-specific integrase -
H3G96_RS28785 136606..137610 - 1005 WP_011977814.1 hypothetical protein -
H3G96_RS28790 137640..137843 - 204 WP_011977813.1 hypothetical protein -
H3G96_RS28795 137889..138410 - 522 WP_013214008.1 hypothetical protein -
H3G96_RS28800 138468..138860 - 393 WP_011977811.1 hypothetical protein -
H3G96_RS28805 138897..139841 - 945 WP_011977810.1 hypothetical protein -
H3G96_RS28810 140002..140463 - 462 WP_014343465.1 hypothetical protein -
H3G96_RS28815 140420..140650 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H3G96_RS28820 140647..141063 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
H3G96_RS28825 141137..142699 + 1563 WP_004206609.1 AAA family ATPase -
H3G96_RS28830 142684..143706 + 1023 WP_000361404.1 helicase UvrD -
H3G96_RS28835 143962..144659 + 698 Protein_184 IS1 family transposase -
H3G96_RS28840 144688..144960 + 273 Protein_185 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB - 1..154728 154728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T184612 WP_001044770.1 NZ_CP066536:140647-141063 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T184612 NZ_CP087695:2373880-2374083 [Xylella taiwanensis]
ATGACGTTGCCGCTTCACTGGCGTACATCCGCACGCGATGACTTGGCCTCGTTGATACGTTTCATCGCTTACGAAAATCC
GCTTACCGCGCGGCGCATGAAAGTACTCATTGAAGCGTCCGTGTTACTAGCCTCCGCACATCCCTACATGTTCCGACCTG
GCCGTGTACCAGGGACACGAGAGATCGTGGCCCACCCGAACTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT184612 WP_001261282.1 NZ_CP066536:140420-140650 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT184612 NZ_CP087695:2373689-2373883 [Xylella taiwanensis]
ATGAAAACCACGCCGCTCGACCCGATCATTTCCGAGTTCGCCACCGAAGAACAGGCGGCCAGCTACGACCGTTGGTTCCG
CGCCAAGGTCCAGGCAAGCCTGGACGATTCGCGCCCAAGCGTTCCACACGATCAAGTGATGGCTGAGATGGATGCGATCA
TCGCTGAAGCCGAGCAGCATCGTAAGCAAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References