184604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4747970..4748624 Replicon chromosome
Accession NZ_CP066534
Organism Klebsiella pneumoniae strain WCHKP090374

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag H3G96_RS23295 Protein ID WP_004144731.1
Coordinates 4747970..4748377 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H3G96_RS23300 Protein ID WP_002916312.1
Coordinates 4748358..4748624 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G96_RS23275 4743970..4745703 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
H3G96_RS23280 4745709..4746422 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H3G96_RS23285 4746445..4747341 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H3G96_RS23290 4747442..4747963 + 522 WP_002916308.1 flavodoxin FldB -
H3G96_RS23295 4747970..4748377 - 408 WP_004144731.1 protein YgfX Toxin
H3G96_RS23300 4748358..4748624 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H3G96_RS23305 4748870..4749853 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
H3G96_RS23310 4750004..4750663 - 660 WP_002916317.1 hemolysin III family protein -
H3G96_RS23315 4750827..4751138 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
H3G96_RS23320 4751188..4751916 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H3G96_RS23325 4752035..4753468 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T184604 WP_004144731.1 NZ_CP066534:c4748377-4747970 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T184604 NZ_CP087694:c1858938-1858735 [Xylella taiwanensis]
ATGACGTTGCCGCTTCACTGGCGTACATCCGCACGCGATGACTTGGCCTCGTTGATACGTTTCATCGCTTACGAAAATCC
GCTTACCGCGCGGCGCATGAAAGTACTCATTGAAGCGTCCGTGTTACTAGCCTCCGCACATCCCTACATGTTCCGACCTG
GCCGTGTACCAGGGACACGAGAGATCGTGGCCCACCCGAACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT184604 WP_002916312.1 NZ_CP066534:c4748624-4748358 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT184604 NZ_CP087694:c1859129-1858935 [Xylella taiwanensis]
ATGAAAACCACGCCGCTCGACCCGATCATTTCCGAGTTCGCCACCGAAGAACAGGCGGCCAGCTACGACCGTTGGTTCCG
CGCCAAGGTCCAGGCAAGCCTGGACGATTCGCGCCCAAGCGTTCCACACGATCAAGTGATGGCTGAGATGGATGCGATCA
TCGCTGAAGCCGAGCAGCATCGTAAGCAAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References