184594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1435692..1436311 Replicon chromosome
Accession NZ_CP066534
Organism Klebsiella pneumoniae strain WCHKP090374

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H3G96_RS06915 Protein ID WP_002892050.1
Coordinates 1435692..1435910 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H3G96_RS06920 Protein ID WP_002892066.1
Coordinates 1435937..1436311 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G96_RS06880 1431739..1432002 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
H3G96_RS06885 1432002..1432142 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H3G96_RS06890 1432139..1432837 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
H3G96_RS06895 1432938..1434389 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H3G96_RS06900 1434364..1434834 - 471 WP_002892026.1 YlaC family protein -
H3G96_RS06905 1434855..1434995 + 141 WP_004147370.1 hypothetical protein -
H3G96_RS06910 1434967..1435533 - 567 WP_002892030.1 maltose O-acetyltransferase -
H3G96_RS06915 1435692..1435910 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H3G96_RS06920 1435937..1436311 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H3G96_RS06925 1436797..1439943 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
H3G96_RS06930 1439966..1441159 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184594 WP_002892050.1 NZ_CP066534:c1435910-1435692 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184594 NZ_CP087692:c2665578-2665324 [Xylella taiwanensis]
ATGAAGCGTAAGCACGCTAAGACCCTCAGCACCATAGACACGCGCCCTGTTTCCGCCAACATCCAATGGCGCGATATTGA
AGCACTCTTCTTGGAGCTTGGAGCGACAGTAGAAGAACGTGAAGGGTCTCGTGTGCTGGTGCGGCTGTTCGGTGAACGCC
GTGTATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGCGCTGTTGAATCGATCCGAGCTTGGTTGAAATCGAAC
GGAGTGACACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184594 WP_002892066.1 NZ_CP066534:c1436311-1435937 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184594 NZ_CP087692:c2665327-2664992 [Xylella taiwanensis]
ATGAAAAACATCATGACCATTGAAGGCTTCAAAGCCATCATTACCTATGATCCGGATATCGACATGTTTCGCGGTGAGTT
TGTCGGTATCAATGGCGGTGCTGATTTCTATGCCAAAGACCTCAAGGGCCTTCGTCGAGAAGGGGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCGAAGAAGATGACGTCGAACCACGCAAATCCTACTCAGGGAAGTTCAATGCAAGGATCTCTCCT
GAACTCCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGAATCAGTTTGAACCAATTTGTAGAACAGGCGATTCAGCA
TGAAATCCACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References