Detailed information of TA system TA184587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 7264..7844
• Replicon: plasmid p2_090361
• Accession: NZ_CP066532
• Organism: Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8J3DTL7
• Locus tag: H3G66_RS28970
• Protein ID: WP_071177730.1
• Coordinates: 7530..7844 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X1PRM1
• Locus tag: H3G66_RS28965
• Protein ID: WP_000093040.1
• Coordinates: 7264..7542 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3G66_RS28945	3705..5192	-	1488	WP_004178082.1	group II intron reverse transcriptase/maturase	-
H3G66_RS28950	5837..6082	+	246	WP_032440458.1	hypothetical protein	-
H3G66_RS28955	6356..6727	+	372	WP_001237044.1	cell envelope integrity protein TolA	-
H3G66_RS28960	6724..6930	+	207	Protein_6	TonB family protein	-
H3G66_RS28965	7264..7542	+	279	WP_000093040.1	CopG family ribbon-helix-helix protein	Antitoxin
H3G66_RS28970	7530..7844	+	315	WP_071177730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3G66_RS28975	8008..8436	+	429	WP_001140599.1	hypothetical protein	-
H3G66_RS28980	8462..8641	+	180	WP_000165970.1	Rop family plasmid primer RNA-binding protein	-
H3G66_RS28985	8668..9198	-	531	WP_071177729.1	hypothetical protein	-
H3G66_RS28990	9205..9936	-	732	WP_071177728.1	replication-relaxation family protein	-
H3G66_RS28995	9936..11900	-	1965	WP_071177727.1	TraM recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..11970	11970

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11805.73 Da
• Isoelectric Point: 9.8324

>T184587 WP_071177730.1 NZ_CP066532:7530-7844 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Nucleotide

• Length: 315 bp

>T184587 NZ_CP087691:c1455497-1455225 [Xylella taiwanensis]
ATGCGCCGTCCTGCTTATTCTTCGCAGTTCAAGCGTGATGTGCGAGTGTCTCAGAAGCGCGGTAAGGACATAGAGAAACT
TAAGATTCTAATAACTTTGCTGATTGAGGGTAGTCCGTTGCCTGCGATGTATTTGGATCATCCGCTTAAGGGGCAGTGGC
GTAGTTTCCGGGATGCTCATGTTGAGCCGGATTGGTTGTTAATCTATAAGGTTGATGGTGATGTGGTGCGCTTTGAGCGT
ACTGGTCGTCATGCTGATTTGTTCGACGATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10709.73 Da
• Isoelectric Point: 4.7561

>AT184587 WP_000093040.1 NZ_CP066532:7264-7542 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Nucleotide

• Length: 279 bp

>AT184587 NZ_CP087691:c1455757-1455497 [Xylella taiwanensis]
ATGGCTGCAAATGCACTTGTGCGTGCCAGAGTTGATGAGGCTCTTAAAGATGAGGCCGCTTCTGTACTTGCGACGATGGG
CCTTACCGTATCTGATCTTATACGTATCACCTTGACTAAAGTGGCTCGTGAAAAAATGTTGCCTTTTGAGATGCACTCAC
CTAATAGGCTTACGGTTGAGACTTTTGTTAAAAGTGAGTGTGGTGAGGATGTGCATTATGCTGAAAGTGCTGATGCCATG
TTTAAAGATCTTGGTATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X1PRM1