Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4823359..4823875 Replicon chromosome
Accession NZ_CP066528
Organism Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag H3G66_RS23785 Protein ID WP_002886902.1
Coordinates 4823359..4823643 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H3G66_RS23790 Protein ID WP_002886901.1
Coordinates 4823633..4823875 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G66_RS23770 4820018..4820155 + 138 Protein_4664 MurR/RpiR family transcriptional regulator -
H3G66_RS23775 4820512..4822650 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
H3G66_RS23780 4822891..4823355 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H3G66_RS23785 4823359..4823643 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3G66_RS23790 4823633..4823875 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H3G66_RS23795 4823953..4825863 - 1911 WP_004152270.1 BglG family transcription antiterminator -
H3G66_RS23800 4825886..4827040 - 1155 WP_002886900.1 lactonase family protein -
H3G66_RS23805 4827106..4827846 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184574 WP_002886902.1 NZ_CP066528:c4823643-4823359 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184574 NZ_CP087689:2305498-2305776 [Xylella taiwanensis]
ATGATTAAAACCTTTGCCGACCAGGACACGGAATCTTTGTTCAACGGGTCACGGGTACGTCGCTTTATTCACATAGAAGC
GGTCGCACGCCGGAAGCTGATTCAATTGCATGCAGCAGCGACCTTGAGCTTTCTCAATGCGCCGCCTGGTAATCGGCTTG
AAACCTTAAAAGGGGACCGCCAAGGGCAGCACAGCATCCGTATCAACAATCAATTCCGCCTCTGTTTCATTTGGGAAAAC
GGCGATGCCTATCAGGTTGAAATTGTCGATTATCACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184574 WP_002886901.1 NZ_CP066528:c4823875-4823633 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184574 NZ_CP087689:2305780-2306079 [Xylella taiwanensis]
ATGAGCATGTCCAAGACACTTCCCCCCATTCACCCAGGAGAAATTCTCCGGGAAGAATTTATGGCCCCTCTAGGCTTATC
CAGCAATGCGCTGGCCAAGGCGATTGGCGTGACGGCGGCACGGATCAACGAGATTGTGCGCGAACGACGTGGGATCACGG
CGGATACTGCACTGCGTCTGGCACGTTACTTTGGCACCGATCCGCAAAGCTGGCTGAATCTGGAACAGCACTATGCACTC
GAATGCGCCAAACGCGACCTTGGAGAGGCCCTGTCACGTATTCACCCTCGCGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References