Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4106070..4106689 Replicon chromosome
Accession NZ_CP066528
Organism Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H3G66_RS20350 Protein ID WP_002892050.1
Coordinates 4106471..4106689 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H3G66_RS20345 Protein ID WP_002892066.1
Coordinates 4106070..4106444 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G66_RS20335 4101222..4102415 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H3G66_RS20340 4102438..4105584 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
H3G66_RS20345 4106070..4106444 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H3G66_RS20350 4106471..4106689 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H3G66_RS20355 4106848..4107414 + 567 WP_002892030.1 maltose O-acetyltransferase -
H3G66_RS20360 4107386..4107526 - 141 WP_004147370.1 hypothetical protein -
H3G66_RS20365 4107547..4108017 + 471 WP_002892026.1 YlaC family protein -
H3G66_RS20370 4107992..4109443 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H3G66_RS20375 4109544..4110242 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H3G66_RS20380 4110239..4110379 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H3G66_RS20385 4110379..4110642 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184572 WP_002892050.1 NZ_CP066528:4106471-4106689 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184572 NZ_CP087689:39115-39438 [Xylella taiwanensis]
ATGACTCAACGCGGCGACCTTGTAACGGTTTCCCTGCAAGGCGATTATGGCAAACCTAGACCGGCGTTAATCCTCCAATC
AGACCTGCTGATGGAGCTAGATAGTGTCGTACTGTGTCCGGTCACAAGTGAGCTACGTAATGCGATATTTCGCATCACCG
TTGAACCAAACATAGCCAATGGGCTACGGACGCTCTCGCAAATCATGGTAGACAAAATTTCAACACTGCCGCGTAGCAAA
ATCAGCAAACCTTTTGGACATCTCAATGACGAGAGGATAAAAGCAGTAGAAAAAGCACTGTTGCTCATCGTTGGTATCAT
CTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184572 WP_002892066.1 NZ_CP066528:4106070-4106444 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184572 NZ_CP087689:38897-39118 [Xylella taiwanensis]
ATGGCATTCATTCACGAACCGACTAGCAAAGTAGCTCGCCACCGAAAGCAAATGCGCGCAGCGGGATTACGTCCTGTCCA
GTTCTGGGTACCGGATACGCGCACACCGGAATTCGCCGCTGAAATTCGGAGCCAGTGCAGGAGCCTGAAGAACGACCCGG
AAGAAGCTGACGCTTTGCGCTTCACCGAAGAAGCCATAACCCATATTGAAGGCTGGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References