Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2734308..2735896 Replicon chromosome
Accession NZ_CP066528
Organism Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag H3G66_RS13520 Protein ID WP_004199851.1
Coordinates 2734308..2735630 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag H3G66_RS13525 Protein ID WP_002904790.1
Coordinates 2735630..2735896 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G66_RS13505 2729373..2731874 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
H3G66_RS13510 2731862..2732866 + 1005 WP_004199852.1 type 1 fimbrial protein -
H3G66_RS13515 2732999..2734291 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
H3G66_RS13520 2734308..2735630 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
H3G66_RS13525 2735630..2735896 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H3G66_RS13530 2736162..2736488 - 327 WP_002904788.1 hydroxyisourate hydrolase -
H3G66_RS13535 2736485..2736985 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
H3G66_RS13540 2736963..2738342 - 1380 WP_004199850.1 purine permease -
H3G66_RS13545 2738688..2739842 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
H3G66_RS13550 2739823..2740746 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T184571 WP_004199851.1 NZ_CP066528:c2735630-2734308 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T184571 NZ_CP087689:c31072-30800 [Xylella taiwanensis]
ATGCGCCGTCCTGCTTATTCTTCGCAGTTCAAGCGTGATGTGCGAGTGTCTCAGAAGCGCGGTAAGGACATAGAGAAACT
TAAGATTCTAATAACTTTGCTGATTGAGGGTAGTCCGTTGCCTGCGATGTATTTGGATCATCCGCTTAAGGGGCAGTGGC
GTAGTTTCCGGGATGCTCATGTTGAGCCGGATTGGTTGTTAATCTATAAGGTTGATGGTGATGTGGTGCGCTTTGAGCGT
ACTGGTCGTCATGCTGATTTGTTCGACGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT184571 WP_002904790.1 NZ_CP066528:c2735896-2735630 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT184571 NZ_CP087689:c31332-31072 [Xylella taiwanensis]
ATGGCTGCAAATGCACTTGTGCGTGCCAGAGTTGATGAGGCTCTTAAAGATGAGGCCGCTTCTGTACTTGCGACGATGGG
CCTTACCGTATCTGATCTTATACGTATCACCTTGACTAAAGTGGCTCGTGAAAAAATGTTGCCTTTTGAGATGCACTCAC
CTAATAGGCTTACGGTTGAGACTTTTGTTAAAAGTGAGTGTGGTGAGGATGTGCATTATGCTGAAAGTGCTGATGCCATG
TTTAAAGATCTTGGTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References