Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871520..872174 Replicon chromosome
Accession NZ_CP066528
Organism Klebsiella pneumoniae strain WCHKP090361

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag H3G66_RS04400 Protein ID WP_004144731.1
Coordinates 871767..872174 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H3G66_RS04395 Protein ID WP_002916312.1
Coordinates 871520..871786 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G66_RS04370 866676..868109 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
H3G66_RS04375 868228..868956 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H3G66_RS04380 869006..869317 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
H3G66_RS04385 869481..870140 + 660 WP_002916317.1 hemolysin III family protein -
H3G66_RS04390 870291..871274 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
H3G66_RS04395 871520..871786 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H3G66_RS04400 871767..872174 + 408 WP_004144731.1 protein YgfX Toxin
H3G66_RS04405 872181..872702 - 522 WP_002916308.1 flavodoxin FldB -
H3G66_RS04410 872803..873699 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H3G66_RS04415 873722..874435 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H3G66_RS04420 874441..876174 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T184562 WP_004144731.1 NZ_CP066528:871767-872174 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T184562 NZ_CP087686:c2627447-2627193 [Xylella taiwanensis]
ATGAAGCGTAAGCACGCTAAGACCCTCAGCACCATAGACACGCGCCCTGTTTCCGCCAACATCCAATGGCGCGATATTGA
AGCACTCTTCTTGGAGCTTGGAGCGACAGTAGAAGAACGTGAAGGGTCTCGTGTGCTGGTGCGGCTGTTCGGTGAACGCC
GTGTATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGCGCTGTTGAATCGATCCGAGCTTGGTTGAAATCGAAC
GGAGTGACACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT184562 WP_002916312.1 NZ_CP066528:871520-871786 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT184562 NZ_CP087686:c2627196-2626861 [Xylella taiwanensis]
ATGAAAAACATCATGACCATTGAAGGCTTCAAAGCCATCATTACCTATGATCCGGATATCGACATGTTTCGCGGTGAGTT
TGTCGGTATCAATGGCGGTGCTGATTTCTATGCCAAAGACCTCAAGGGCCTTCGTCGAGAAGGGGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCGAAGAAGATGACGTCGAACCACGCAAATCCTACTCAGGGAAGTTCAATGCAAGGATCTCTCCT
GAACTCCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGAATCAGTTTGAACCAATTTGTAGAACAGGCGATTCAGCA
TGAAATCCACATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References