Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4904596..4905112 Replicon chromosome
Accession NZ_CP066523
Organism Klebsiella pneumoniae strain WCHKP090357

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag H3G71_RS24175 Protein ID WP_002886902.1
Coordinates 4904596..4904880 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H3G71_RS24180 Protein ID WP_002886901.1
Coordinates 4904870..4905112 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G71_RS24150 4900080..4900388 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
H3G71_RS24155 4900473..4900646 + 174 WP_002886906.1 hypothetical protein -
H3G71_RS24160 4900649..4901392 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H3G71_RS24165 4901749..4903887 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
H3G71_RS24170 4904128..4904592 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H3G71_RS24175 4904596..4904880 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3G71_RS24180 4904870..4905112 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H3G71_RS24185 4905190..4907100 - 1911 WP_004152270.1 BglG family transcription antiterminator -
H3G71_RS24190 4907123..4908277 - 1155 WP_002886900.1 lactonase family protein -
H3G71_RS24195 4908343..4909083 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184545 WP_002886902.1 NZ_CP066523:c4904880-4904596 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184545 NZ_CP087683:c450939-450736 [Xylella taiwanensis]
ATGACGTTGCCGCTTCACTGGCGTACATCCGCACGCGATGACTTGGCCTCGTTGATACGTTTCATCGCTTACGAAAATCC
GCTTACCGCGCGGCGCATGAAAGTACTCATTGAAGCGTCCGTGTTACTAGCCTCCGCACATCCCTACATGTTCCGACCTG
GCCGTGTACCAGGGACACGAGAGATCGTGGCCCACCCGAACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184545 WP_002886901.1 NZ_CP066523:c4905112-4904870 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184545 NZ_CP087683:c451130-450936 [Xylella taiwanensis]
ATGAAAACCACGCCGCTCGACCCGATCATTTCCGAGTTCGCCACCGAAGAACAGGCGGCCAGCTACGACCGTTGGTTCCG
CGCCAAGGTCCAGGCAAGCCTGGACGATTCGCGCCCAAGCGTTCCACACGATCAAGTGATGGCTGAGATGGATGCGATCA
TCGCTGAAGCCGAGCAGCATCGTAAGCAAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References