Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4189325..4189944 Replicon chromosome
Accession NZ_CP066523
Organism Klebsiella pneumoniae strain WCHKP090357

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H3G71_RS20760 Protein ID WP_002892050.1
Coordinates 4189726..4189944 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H3G71_RS20755 Protein ID WP_002892066.1
Coordinates 4189325..4189699 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G71_RS20745 4184477..4185670 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H3G71_RS20750 4185693..4188839 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
H3G71_RS20755 4189325..4189699 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H3G71_RS20760 4189726..4189944 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H3G71_RS20765 4190103..4190669 + 567 WP_002892030.1 maltose O-acetyltransferase -
H3G71_RS20770 4190641..4190781 - 141 WP_004147370.1 hypothetical protein -
H3G71_RS20775 4190802..4191272 + 471 WP_002892026.1 YlaC family protein -
H3G71_RS20780 4191247..4192698 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H3G71_RS20785 4192799..4193497 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H3G71_RS20790 4193494..4193634 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H3G71_RS20795 4193634..4193897 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184543 WP_002892050.1 NZ_CP066523:4189726-4189944 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184543 NZ_CP087681:2789226-2789642 [Xylella taiwanensis]
TTGAGCGGATATTTGCTCGATACGAACATCATTAGCGACATGATCCGTAATCCGTTTGGACTAGTTGCGTGTCGCATTGA
AAAGGTCGATCCAAAAGAGGTTTGCACTAGCATCGTTGTCGCTGCTGAGTTGCGGTATGGTTGTGCAAAGAAAGGATCGA
CCAAGTTGCTTGCGAAGGTGAAGCTCATGCTTGAAACAATTCCTGTGCTGCCTTTGGATATTCCTACCGACGCTGAATAT
GGTCGCATTCGTGCAGAGTTGGAGTCAGTAGGACAAACTATCGGCTTAAATGATCTATTGATAGGTACTCATGCTTATGT
ACTGGGGATGACATTGGTAACGGATAATGTTAAAGAGTTTAAGCGTATTCGTGGCCTTAAGATCGAAAATTGGCTGGAAT
GTGCATCCTCGGTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184543 WP_002892066.1 NZ_CP066523:4189325-4189699 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184543 NZ_CP087681:2788957-2789229 [Xylella taiwanensis]
ATGTCTATTTCTATGCCATCATCTAGACTCAAGGAAGCTAAGCTGTTCCGCAACAATCGCAGTCAGGCCGTGAGAATTCC
GGTTGAGTTTGAATTACCGGGGGATCGAGTATTGATTCATCGCGAGGGTAGCAAGCTCATCATTGAGCCTGTGAGCATGC
CTACCAACATTATAGAATTGTTAGCGCAGTGGAAAACGGAAGATCCGCTTGGACTTGAAGATCAGTTTCCTGAAATTGAG
GACATGCTTGCTAAGCCGGATGACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References