184516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5025963..5027644 Replicon chromosome
Accession NZ_CP066517
Organism Klebsiella pneumoniae strain WCHKP090329

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag H3G99_RS24780 Protein ID WP_002885155.1
Coordinates 5025963..5026880 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag H3G99_RS24785 Protein ID WP_004151732.1
Coordinates 5026886..5027644 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G99_RS24760 5021269..5022789 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
H3G99_RS24765 5022786..5023784 + 999 WP_002885172.1 ribose ABC transporter permease -
H3G99_RS24770 5023815..5024756 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
H3G99_RS24775 5024831..5025838 + 1008 WP_004151731.1 carbohydrate kinase family protein -
H3G99_RS24780 5025963..5026880 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
H3G99_RS24785 5026886..5027644 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
H3G99_RS24790 5027730..5028458 - 729 WP_002885152.1 response regulator transcription factor -
H3G99_RS24795 5028731..5030878 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
H3G99_RS24800 5031108..5031794 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T184516 WP_002885155.1 NZ_CP066517:c5026880-5025963 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T184516 NZ_CP087676:c1859112-1858909 [Xylella taiwanensis]
ATGACGTTGCCGCTTCACTGGCGTACATCCGCACGCGATGACTTGGCCTCGTTGATACGTTTCATCGCTTACGAAAATCC
GCTTACCGCGCGGCGCATGAAAGTACTCATTGAAGCGTCCGTGTTACTAGCCTCCGCACATCCCTACATGTTCCGACCTG
GCCGTGTACCAGGGACACGAGAGATCGTGGCCCACCCGAACTAG

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT184516 WP_004151732.1 NZ_CP066517:c5027644-5026886 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT184516 NZ_CP087676:c1859303-1859109 [Xylella taiwanensis]
ATGAAAACCACGCCGCTCGACCCGATCATTTCCGAGTTCGCCACCGAAGAACAGGCGGCCAGCTACGACCGTTGGTTCCG
CGCCAAGGTCCAGGCAAGCCTGGACGATTCGCGCCCAAGCGTTCCACACGATCAAGTGATGGCTGAGATGGATGCGATCA
TCGCTGAAGCCGAGCAGCATCGTAAGCAAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References