Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4151184..4151803 | Replicon | chromosome |
Accession | NZ_CP066517 | ||
Organism | Klebsiella pneumoniae strain WCHKP090329 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | H3G99_RS20535 | Protein ID | WP_002892050.1 |
Coordinates | 4151585..4151803 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | H3G99_RS20530 | Protein ID | WP_002892066.1 |
Coordinates | 4151184..4151558 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H3G99_RS20520 | 4146336..4147529 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
H3G99_RS20525 | 4147552..4150698 | + | 3147 | WP_020326861.1 | multidrug efflux RND transporter permease subunit | - |
H3G99_RS20530 | 4151184..4151558 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
H3G99_RS20535 | 4151585..4151803 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
H3G99_RS20540 | 4151962..4152528 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
H3G99_RS20545 | 4152500..4152640 | - | 141 | WP_004147370.1 | hypothetical protein | - |
H3G99_RS20550 | 4152661..4153131 | + | 471 | WP_002892026.1 | YlaC family protein | - |
H3G99_RS20555 | 4153106..4154557 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
H3G99_RS20560 | 4154658..4155356 | + | 699 | WP_002892021.1 | GNAT family N-acetyltransferase | - |
H3G99_RS20565 | 4155353..4155493 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
H3G99_RS20570 | 4155493..4155756 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T184513 WP_002892050.1 NZ_CP066517:4151585-4151803 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T184513 NZ_CP087676:c31269-30853 [Xylella taiwanensis]
TTGAGCGGATATTTGCTCGATACGAACATCATTAGCGACATGATCCGTAATCCGTTTGGACTAGTTGCGTGTCGCATTGA
AAAGGTCGATCCAAAAGAGGTTTGCACTAGCATCGTTGTCGCTGCTGAGTTGCGGTATGGTTGTGCAAAGAAAGGATCGA
CCAAGTTGCTTGCGAAGGTGAAGCTCATGCTTGAAACAATTCCTGTGCTGCCTTTGGATATTCCTACCGACGCTGAATAT
GGTCGCATTCGTGCAGAGTTGGAGTCAGTAGGACAAACTATCGGCTTAAATGATCTATTGATAGGTACTCATGCTTATGT
ACTGGGGATGACATTGGTAACGGATAATGTTAAAGAGTTTAAGCGTATTCGTGGCCTTAAGATCGAAAATTGGCTGGAAT
GTGCATCCTCGGTTTAG
TTGAGCGGATATTTGCTCGATACGAACATCATTAGCGACATGATCCGTAATCCGTTTGGACTAGTTGCGTGTCGCATTGA
AAAGGTCGATCCAAAAGAGGTTTGCACTAGCATCGTTGTCGCTGCTGAGTTGCGGTATGGTTGTGCAAAGAAAGGATCGA
CCAAGTTGCTTGCGAAGGTGAAGCTCATGCTTGAAACAATTCCTGTGCTGCCTTTGGATATTCCTACCGACGCTGAATAT
GGTCGCATTCGTGCAGAGTTGGAGTCAGTAGGACAAACTATCGGCTTAAATGATCTATTGATAGGTACTCATGCTTATGT
ACTGGGGATGACATTGGTAACGGATAATGTTAAAGAGTTTAAGCGTATTCGTGGCCTTAAGATCGAAAATTGGCTGGAAT
GTGCATCCTCGGTTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT184513 WP_002892066.1 NZ_CP066517:4151184-4151558 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT184513 NZ_CP087676:c31538-31266 [Xylella taiwanensis]
ATGTCTATTTCTATGCCATCATCTAGACTCAAGGAAGCTAAGCTGTTCCGCAACAATCGCAGTCAGGCCGTGAGAATTCC
GGTTGAGTTTGAATTACCGGGGGATCGAGTATTGATTCATCGCGAGGGTAGCAAGCTCATCATTGAGCCTGTGAGCATGC
CTACCAACATTATAGAATTGTTAGCGCAGTGGAAAACGGAAGATCCGCTTGGACTTGAAGATCAGTTTCCTGAAATTGAG
GACATGCTTGCTAAGCCGGATGACATATTTTGA
ATGTCTATTTCTATGCCATCATCTAGACTCAAGGAAGCTAAGCTGTTCCGCAACAATCGCAGTCAGGCCGTGAGAATTCC
GGTTGAGTTTGAATTACCGGGGGATCGAGTATTGATTCATCGCGAGGGTAGCAAGCTCATCATTGAGCCTGTGAGCATGC
CTACCAACATTATAGAATTGTTAGCGCAGTGGAAAACGGAAGATCCGCTTGGACTTGAAGATCAGTTTCCTGAAATTGAG
GACATGCTTGCTAAGCCGGATGACATATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |