Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4151184..4151803 Replicon chromosome
Accession NZ_CP066517
Organism Klebsiella pneumoniae strain WCHKP090329

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H3G99_RS20535 Protein ID WP_002892050.1
Coordinates 4151585..4151803 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H3G99_RS20530 Protein ID WP_002892066.1
Coordinates 4151184..4151558 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3G99_RS20520 4146336..4147529 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H3G99_RS20525 4147552..4150698 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
H3G99_RS20530 4151184..4151558 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H3G99_RS20535 4151585..4151803 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H3G99_RS20540 4151962..4152528 + 567 WP_002892030.1 maltose O-acetyltransferase -
H3G99_RS20545 4152500..4152640 - 141 WP_004147370.1 hypothetical protein -
H3G99_RS20550 4152661..4153131 + 471 WP_002892026.1 YlaC family protein -
H3G99_RS20555 4153106..4154557 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H3G99_RS20560 4154658..4155356 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H3G99_RS20565 4155353..4155493 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H3G99_RS20570 4155493..4155756 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184513 WP_002892050.1 NZ_CP066517:4151585-4151803 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184513 NZ_CP087676:c31269-30853 [Xylella taiwanensis]
TTGAGCGGATATTTGCTCGATACGAACATCATTAGCGACATGATCCGTAATCCGTTTGGACTAGTTGCGTGTCGCATTGA
AAAGGTCGATCCAAAAGAGGTTTGCACTAGCATCGTTGTCGCTGCTGAGTTGCGGTATGGTTGTGCAAAGAAAGGATCGA
CCAAGTTGCTTGCGAAGGTGAAGCTCATGCTTGAAACAATTCCTGTGCTGCCTTTGGATATTCCTACCGACGCTGAATAT
GGTCGCATTCGTGCAGAGTTGGAGTCAGTAGGACAAACTATCGGCTTAAATGATCTATTGATAGGTACTCATGCTTATGT
ACTGGGGATGACATTGGTAACGGATAATGTTAAAGAGTTTAAGCGTATTCGTGGCCTTAAGATCGAAAATTGGCTGGAAT
GTGCATCCTCGGTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184513 WP_002892066.1 NZ_CP066517:4151184-4151558 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184513 NZ_CP087676:c31538-31266 [Xylella taiwanensis]
ATGTCTATTTCTATGCCATCATCTAGACTCAAGGAAGCTAAGCTGTTCCGCAACAATCGCAGTCAGGCCGTGAGAATTCC
GGTTGAGTTTGAATTACCGGGGGATCGAGTATTGATTCATCGCGAGGGTAGCAAGCTCATCATTGAGCCTGTGAGCATGC
CTACCAACATTATAGAATTGTTAGCGCAGTGGAAAACGGAAGATCCGCTTGGACTTGAAGATCAGTTTCCTGAAATTGAG
GACATGCTTGCTAAGCCGGATGACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References