Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2125866..2126395 Replicon chromosome
Accession NZ_CP066492
Organism Staphylococcus aureus strain nan_175_F371_ch

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JF380_RS10655 Protein ID WP_000621175.1
Coordinates 2125866..2126228 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag JF380_RS10660 Protein ID WP_000948331.1
Coordinates 2126225..2126395 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF380_RS10635 2122844..2123614 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
JF380_RS10640 2123589..2124068 - 480 WP_001190829.1 anti-sigma B factor RsbW -
JF380_RS10645 2124070..2124396 - 327 WP_001052491.1 anti-sigma factor antagonist -
JF380_RS10650 2124515..2125516 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
JF380_RS10655 2125866..2126228 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JF380_RS10660 2126225..2126395 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JF380_RS10665 2126480..2127628 - 1149 WP_001281154.1 alanine racemase -
JF380_RS10670 2127694..2128053 - 360 WP_000581197.1 holo-ACP synthase -
JF380_RS10675 2128057..2128548 - 492 WP_001205912.1 PH domain-containing protein -
JF380_RS10680 2128535..2130118 - 1584 WP_001294620.1 PH domain-containing protein -
JF380_RS10685 2130111..2130590 - 480 WP_001287079.1 hypothetical protein -
JF380_RS10690 2130799..2131359 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T184490 WP_000621175.1 NZ_CP066492:c2126228-2125866 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T184490 NZ_CP087669:c5245579-5245196 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT184490 WP_000948331.1 NZ_CP066492:c2126395-2126225 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT184490 NZ_CP087669:c5245821-5245579 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTACTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References