Detailed information of TA system TA184488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1942718..1943518
• Replicon: chromosome
• Accession: NZ_CP066492
• Organism: Staphylococcus aureus strain nan_175_F371_ch

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JF380_RS09595
• Protein ID: WP_198914273.1
• Coordinates: 1943054..1943518 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JF380_RS09590
• Protein ID: WP_198914103.1
• Coordinates: 1942718..1943041 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF380_RS09535	1938114..1938539	-	426	WP_198914094.1	single-stranded DNA-binding protein	-
JF380_RS09540	1938539..1939177	-	639	WP_001043063.1	ERF family protein	-
JF380_RS09545	1939177..1939656	-	480	WP_198914095.1	siphovirus Gp157 family protein	-
JF380_RS09550	1939649..1939885	-	237	WP_198914096.1	hypothetical protein	-
JF380_RS09555	1939894..1940154	-	261	WP_198914097.1	DUF1108 family protein	-
JF380_RS09560	1940290..1940451	-	162	WP_000048132.1	DUF1270 family protein	-
JF380_RS09565	1940466..1940681	-	216	WP_198914098.1	DUF771 domain-containing protein	-
JF380_RS09570	1940697..1941449	-	753	WP_198914099.1	phage antirepressor KilAC domain-containing protein	-
JF380_RS09575	1941637..1941840	-	204	WP_198914100.1	hypothetical protein	-
JF380_RS09580	1941855..1942298	-	444	WP_198914101.1	hypothetical protein	-
JF380_RS09585	1942310..1942558	-	249	WP_198914102.1	helix-turn-helix domain-containing protein	-
JF380_RS09590	1942718..1943041	+	324	WP_198914103.1	helix-turn-helix domain-containing protein	Antitoxin
JF380_RS09595	1943054..1943518	+	465	WP_198914273.1	toxin	Toxin
JF380_RS09600	1944397..1944684	+	288	WP_198914104.1	CPBP family intramembrane metalloprotease	-
JF380_RS09605	1944850..1945914	+	1065	WP_198914105.1	site-specific integrase	-
JF380_RS09650	1947286..1947840	-	555	WP_000132890.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1874070..1947840	73770

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18074.42 Da
• Isoelectric Point: 4.7927

>T184488 WP_198914273.1 NZ_CP066492:1943054-1943518 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHSKLTYGDIGDYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRSLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID

Nucleotide

• Length: 465 bp

>T184488 NZ_CP087669:c4766845-4766561 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12415.09 Da
• Isoelectric Point: 9.4641

>AT184488 WP_198914103.1 NZ_CP066492:1942718-1943041 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDFADYIRSKRK

Nucleotide

• Length: 324 bp

>AT184488 NZ_CP087669:c4767077-4766835 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA