184474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2169018..2169532 Replicon chromosome
Accession NZ_CP066488
Organism Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag JF379_RS10785 Protein ID WP_000581793.1
Coordinates 2169018..2169227 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JF379_RS10790 Protein ID WP_000138932.1
Coordinates 2169239..2169532 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF379_RS10765 2164527..2165885 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JF379_RS10770 2165900..2166970 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
JF379_RS10775 2167288..2168490 + 1203 WP_001109939.1 rod shape-determining protein RodA -
JF379_RS10780 2168753..2168890 - 138 WP_000828354.1 hypothetical protein -
JF379_RS10785 2169018..2169227 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
JF379_RS10790 2169239..2169532 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JF379_RS10795 2169698..2171182 + 1485 WP_000571549.1 cardiolipin synthase -
JF379_RS10800 2171210..2171857 + 648 WP_001187628.1 HD domain-containing protein -
JF379_RS10805 2172471..2173343 - 873 WP_111031438.1 membrane protein insertase YidC -
JF379_RS10810 2173429..2174070 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T184474 WP_000581793.1 NZ_CP066488:c2169227-2169018 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T184474 NZ_CP087666:111232-111381 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT184474 WP_000138932.1 NZ_CP066488:c2169532-2169239 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT184474 NZ_CP087666:c111187-111128 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References