Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1963584..1964384 Replicon chromosome
Accession NZ_CP066488
Organism Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JF379_RS09605 Protein ID WP_198914273.1
Coordinates 1963920..1964384 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JF379_RS09600 Protein ID WP_198914103.1
Coordinates 1963584..1963907 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF379_RS09545 1958879..1959295 - 417 WP_198917894.1 single-stranded DNA-binding protein -
JF379_RS09550 1959295..1959942 - 648 WP_198917895.1 ERF family protein -
JF379_RS09555 1959943..1960479 - 537 WP_198917896.1 host-nuclease inhibitor Gam family protein -
JF379_RS09560 1960492..1960752 - 261 WP_198917897.1 DUF1108 family protein -
JF379_RS09565 1960794..1961060 - 267 WP_198917898.1 DUF2482 family protein -
JF379_RS09570 1961152..1961313 - 162 WP_000048132.1 DUF1270 family protein -
JF379_RS09575 1961328..1961543 - 216 WP_198914098.1 DUF771 domain-containing protein -
JF379_RS09580 1961559..1962311 - 753 WP_198914099.1 phage antirepressor KilAC domain-containing protein -
JF379_RS09585 1962499..1962702 - 204 WP_198914100.1 hypothetical protein -
JF379_RS09590 1962717..1963160 - 444 WP_198914101.1 hypothetical protein -
JF379_RS09595 1963172..1963420 - 249 WP_198917899.1 helix-turn-helix domain-containing protein -
JF379_RS09600 1963584..1963907 + 324 WP_198914103.1 helix-turn-helix domain-containing protein Antitoxin
JF379_RS09605 1963920..1964384 + 465 WP_198914273.1 toxin Toxin
JF379_RS09610 1964894..1965553 + 660 WP_198917900.1 CPBP family intramembrane metalloprotease -
JF379_RS09615 1965719..1966783 + 1065 WP_198917901.1 site-specific integrase -
JF379_RS09660 1968153..1968707 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1882282..1990177 107895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18074.42 Da        Isoelectric Point: 4.7927

>T184471 WP_198914273.1 NZ_CP066488:1963920-1964384 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHSKLTYGDIGDYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRSLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID

Download         Length: 465 bp

>T184471 NZ_CP087664:c105513-105043 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12415.09 Da        Isoelectric Point: 9.4641

>AT184471 WP_198914103.1 NZ_CP066488:1963584-1963907 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDFADYIRSKRK

Download         Length: 324 bp

>AT184471 NZ_CP087664:c105953-105510 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References