Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 26846..27365 Replicon plasmid p93_3_34kb
Accession NZ_CP066483
Organism Enterococcus faecium strain Dallas 93_3

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP71_RS15315 Protein ID WP_000588503.1
Coordinates 27108..27365 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP71_RS15310 Protein ID WP_000388479.1
Coordinates 26846..27115 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP71_RS15285 22140..23617 + 1478 Protein_24 type I restriction-modification system subunit M -
JCP71_RS15290 23640..24320 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP71_RS15295 24833..25513 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP71_RS15300 25589..26155 + 567 Protein_27 hypothetical protein -
JCP71_RS15305 26536..26715 + 180 WP_001120991.1 hypothetical protein -
JCP71_RS15310 26846..27115 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP71_RS15315 27108..27365 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP71_RS15320 27824..28828 + 1005 WP_000455809.1 hypothetical protein -
JCP71_RS15325 28993..29607 - 615 WP_001261742.1 recombinase family protein -
JCP71_RS15330 30057..31382 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP71_RS15335 31375..31725 + 351 WP_000568378.1 hypothetical protein -
JCP71_RS15340 31722..31901 + 180 WP_001021554.1 hypothetical protein -
JCP71_RS15345 32037..32327 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / VanHAX - 1..34144 34144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184467 WP_000588503.1 NZ_CP066483:27108-27365 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184467 NZ_CP087663:c4882012-4881728 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184467 WP_000388479.1 NZ_CP066483:26846-27115 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184467 NZ_CP087663:c4882244-4882002 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References