Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2543778..2544307 Replicon chromosome
Accession NZ_CP066473
Organism Enterococcus faecium strain Dallas 93_2

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag JCP72_RS12270 Protein ID WP_002294198.1
Coordinates 2543778..2544044 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag JCP72_RS12275 Protein ID WP_002317080.1
Coordinates 2544044..2544307 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP72_RS12245 2539145..2540320 + 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -
JCP72_RS12250 2540324..2540965 + 642 WP_002293405.1 ABC transporter permease -
JCP72_RS12255 2540962..2541879 + 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
JCP72_RS12260 2541876..2542547 + 672 WP_002319469.1 ABC transporter permease -
JCP72_RS12265 2543089..2543577 - 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
JCP72_RS12270 2543778..2544044 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
JCP72_RS12275 2544044..2544307 - 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP72_RS12280 2544782..2544967 + 186 WP_002294201.1 hypothetical protein -
JCP72_RS12285 2545109..2546932 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T184458 WP_002294198.1 NZ_CP066473:c2544044-2543778 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T184458 NZ_CP087660:111398-111547 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT184458 WP_002317080.1 NZ_CP066473:c2544307-2544044 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp

>AT184458 NZ_CP087660:c111353-111294 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References