Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 190891..191420 | Replicon | chromosome |
Accession | NZ_CP066457 | ||
Organism | Enterococcus faecium strain Dallas 87_1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | C9B8W9 |
Locus tag | JCP85_RS00945 | Protein ID | WP_002294198.1 |
Coordinates | 191154..191420 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A1S8JTG2 |
Locus tag | JCP85_RS00940 | Protein ID | WP_002317080.1 |
Coordinates | 190891..191154 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JCP85_RS00930 | 188266..190089 | + | 1824 | WP_002294202.1 | APC family permease | - |
JCP85_RS00935 | 190231..190416 | - | 186 | WP_002294201.1 | hypothetical protein | - |
JCP85_RS00940 | 190891..191154 | + | 264 | WP_002317080.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JCP85_RS00945 | 191154..191420 | + | 267 | WP_002294198.1 | Txe/YoeB family addiction module toxin | Toxin |
JCP85_RS00950 | 191621..192109 | + | 489 | WP_002301120.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
JCP85_RS00955 | 192651..193322 | - | 672 | WP_002319469.1 | ABC transporter permease | - |
JCP85_RS00960 | 193319..194236 | - | 918 | WP_002301114.1 | osmoprotectant ABC transporter substrate-binding protein | - |
JCP85_RS00965 | 194233..194874 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
JCP85_RS00970 | 194878..196053 | - | 1176 | WP_002348889.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | lap | 92929..220120 | 127191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10646.11 Da Isoelectric Point: 9.9931
>T184446 WP_002294198.1 NZ_CP066457:191154-191420 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T184446 NZ_CP087657:880018-880425 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10015.04 Da Isoelectric Point: 4.1844
>AT184446 WP_002317080.1 NZ_CP066457:190891-191154 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL
Download Length: 264 bp
>AT184446 NZ_CP087657:879771-880037 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FMA0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S8JTG2 |