Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 190891..191420 Replicon chromosome
Accession NZ_CP066457
Organism Enterococcus faecium strain Dallas 87_1

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag JCP85_RS00945 Protein ID WP_002294198.1
Coordinates 191154..191420 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag JCP85_RS00940 Protein ID WP_002317080.1
Coordinates 190891..191154 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP85_RS00930 188266..190089 + 1824 WP_002294202.1 APC family permease -
JCP85_RS00935 190231..190416 - 186 WP_002294201.1 hypothetical protein -
JCP85_RS00940 190891..191154 + 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP85_RS00945 191154..191420 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
JCP85_RS00950 191621..192109 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
JCP85_RS00955 192651..193322 - 672 WP_002319469.1 ABC transporter permease -
JCP85_RS00960 193319..194236 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
JCP85_RS00965 194233..194874 - 642 WP_002293405.1 ABC transporter permease -
JCP85_RS00970 194878..196053 - 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lap 92929..220120 127191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T184446 WP_002294198.1 NZ_CP066457:191154-191420 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T184446 NZ_CP087657:880018-880425 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT184446 WP_002317080.1 NZ_CP066457:190891-191154 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp

>AT184446 NZ_CP087657:879771-880037 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References