Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 4521..5040 Replicon plasmid p53_2_11kb
Accession NZ_CP066412
Organism Enterococcus faecium strain Dallas 53_2

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP94_RS15445 Protein ID WP_000588503.1
Coordinates 4783..5040 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP94_RS15440 Protein ID WP_000388479.1
Coordinates 4521..4790 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP94_RS15415 1..1041 + 1041 WP_000997689.1 replication initiator protein A -
JCP94_RS15420 1657..2337 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP94_RS15425 2508..3188 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP94_RS15430 3264..3830 + 567 Protein_3 hypothetical protein -
JCP94_RS15435 4211..4390 + 180 WP_001120991.1 hypothetical protein -
JCP94_RS15440 4521..4790 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP94_RS15445 4783..5040 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP94_RS15450 5499..6503 + 1005 WP_000455809.1 hypothetical protein -
JCP94_RS15455 6668..7282 - 615 WP_001261742.1 recombinase family protein -
JCP94_RS15460 7732..9057 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP94_RS15465 9050..9400 + 351 WP_000568378.1 hypothetical protein -
JCP94_RS15470 9397..9576 + 180 WP_001021554.1 hypothetical protein -
JCP94_RS15475 9712..10002 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11819 11819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184410 WP_000588503.1 NZ_CP066412:4783-5040 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184410 NZ_CP087644:c2863-2597 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184410 WP_000388479.1 NZ_CP066412:4521-4790 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184410 NZ_CP087644:c3071-2847 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References