Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1968796..1969584 Replicon chromosome
Accession NZ_CP066376
Organism Staphylococcus epidermidis strain PH1-28

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ICN77_RS10000 Protein ID WP_002484735.1
Coordinates 1969123..1969584 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ICN77_RS09995 Protein ID WP_002498323.1
Coordinates 1968796..1969110 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN77_RS09940 1963981..1964757 - 777 WP_002468156.1 ATP-binding protein -
ICN77_RS09945 1964758..1965243 - 486 WP_002498316.1 siphovirus Gp157 family protein -
ICN77_RS09950 1965227..1965490 - 264 WP_002468154.1 hypothetical protein -
ICN77_RS09955 1965556..1965738 - 183 WP_002498317.1 hypothetical protein -
ICN77_RS09960 1965735..1965950 - 216 WP_002468180.1 hypothetical protein -
ICN77_RS09965 1966058..1966261 + 204 WP_002468183.1 hypothetical protein -
ICN77_RS09970 1966369..1966857 - 489 WP_002498318.1 ORF6C domain-containing protein -
ICN77_RS09975 1966916..1967296 + 381 WP_002498319.1 DUF2513 domain-containing protein -
ICN77_RS09980 1967288..1967464 - 177 WP_002498320.1 hypothetical protein -
ICN77_RS09985 1967475..1968392 - 918 WP_002498321.1 hypothetical protein -
ICN77_RS09990 1968407..1968643 - 237 WP_198895691.1 helix-turn-helix domain-containing protein -
ICN77_RS09995 1968796..1969110 + 315 WP_002498323.1 helix-turn-helix domain-containing protein Antitoxin
ICN77_RS10000 1969123..1969584 + 462 WP_002484735.1 ImmA/IrrE family metallo-endopeptidase Toxin
ICN77_RS10005 1969753..1969920 + 168 WP_002498324.1 hypothetical protein -
ICN77_RS10010 1969942..1971081 + 1140 WP_002498325.1 CapA family protein -
ICN77_RS10015 1971297..1972346 + 1050 WP_002498326.1 site-specific integrase -
ICN77_RS10020 1972414..1973811 - 1398 WP_002498327.1 Fe-S cluster assembly protein SufB -
ICN77_RS10025 1974017..1974481 - 465 WP_001831954.1 SUF system NifU family Fe-S cluster assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1931567..1973811 42244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17881.48 Da        Isoelectric Point: 5.0503

>T184380 WP_002484735.1 NZ_CP066376:1969123-1969584 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Download         Length: 462 bp

>T184380 NZ_CP066376:1969123-1969584 [Staphylococcus epidermidis]
GTGGGGAAATATGAGGATATGTTAATTGAACATGACTATATTGAAGTCATTGAATGTGATAACTTACCTAAAAGGTTATC
TGGCTTGTGGCTTGGAGATATGATTTTAATTAATCGTAACTTACCTATTACTTCCAAACTTGAAACACTTGCAGAGGAAC
TCGCTCATAACGAACTTACATATGGAAATATAGTTGATCAAAGTAGTTTTAATCATAGAAAATTTGAAGGTTATGCACGT
AGGTTAGCCTATGAAAAGTTAGTCCCTCTTAAAGATATTGTAAAAGCATTTTTGCAAGGCATTCATGACTTGTATGAACT
TGCAAATTTTTTTGAGGTTACAGAAGGTTTTGTCCAACAAAGTATTGCACATTATAAACAAAAATATGGCTTAACAACTC
GATGTGGTGATTATGTTATAGCATTTGAACCTTTAAGAGTTTTTGAGTACAAAGAAATATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12044.60 Da        Isoelectric Point: 5.7723

>AT184380 WP_002498323.1 NZ_CP066376:1968796-1969110 [Staphylococcus epidermidis]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEDVEEQPQHRAAHL
DGDLTDEEWQEILDYAEYIRSKRK

Download         Length: 315 bp

>AT184380 NZ_CP066376:1968796-1969110 [Staphylococcus epidermidis]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATTAAAAATCTTAAAAATGATACTATTGAAAGTATAGCTACTG
CATTAAATGTTAACCCTGCTTTCTTGATGGGTTGGATAGAAGATGTTGAGGAACAACCACAACATCGTGCAGCACATCTT
GATGGTGATTTAACTGACGAAGAATGGCAAGAAATTCTTGATTACGCTGAATACATAAGAAGTAAAAGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References